Evidence map›Paper›PMID 32046536›Full record

ArticleIntegrative cancer therapies

Jianpi-Huayu Formula Inhibits Development of Hepatocellular Carcinoma by Regulating Expression of miR-602, Which Targets the

Yajing Huang, Cheng Zhou, Huihong Wen, Yongxu Chen, Yingjie Xie, Xiaohe Lan, Juze Lin, Xuhui Huang, Yousheng Mo, Cong Yang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yajing HuangGuangzhou University of Chinese Medicine, Guangzhou, China.
Cheng ZhouGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.
Huihong WenGuangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, China.
Yongxu ChenGuangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yingjie XieGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.
Xiaohe LanGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.
Juze LinGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.
Xuhui HuangGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China.
Yousheng MoGuangzhou University of Chinese Medicine, Guangzhou, China.
Cong YangGuangzhou University of Chinese Medicine, Guangzhou, China.
Qi WangGuangzhou University of Chinese Medicine, Guangzhou, China.
Changjun WangGuangzhou University of Chinese Medicine, Guangzhou, China.ORCID 0000-0003-0420-4679
Guangdong Academy of Medical Sciences · CNGuangzhou University of Chinese Medicine · CNGuangzhou First People's Hospital · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear. In this article, we employed an orthotopic transplantation model in nude mice to explore whether JPHY could inhibit the development of HCC by regulating miR-602, which targets the Ras association domain-containing protein 1A (RASSF1A) pathway. HCC SMMC-7721 cells were treated with JPHY to test whether the

Indexed as

Carcinoma, HepatocellularAnimalsCell Line, TumorDrugs, Chinese HerbalGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMiceMice, NudeMicroRNAsSignal TransductionTumor Suppressor ProteinsDrugs, Chinese HerbalMicroRNAsMIRN602 microRNA, humanRASSF1 protein, humanRASSF1 protein, mouseTumor Suppressor Proteinsapoptosishepatocellular carcinomaJianpi-Huayu formulamiR-602RASSF1ASMMC-7721

Identifiers

PMID32046536
PMCPMC7016307
OpenAlexW3005996570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.