ArticleThe American journal of psychiatry2020
Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in
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Article in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 29 citations in OpenAlex.
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Authors and funding
13 authors at 1 institution in 1 country.
Marieke KleinDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Euginia L SinggihDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Anne van RensDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Ditte DemontisDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Anders D BørglumDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Nina Roth MotaDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Anna Castells-NobauDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Lambertus A KiemeneyDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Han G BrunnerDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Alejandro Arias-VasquezDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Annette SchenckDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Monique van der VoetDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Barbara FrankeDepartment of Human Genetics (Klein, Singgih, van Rens, Mota, Castells-Nobau, Brunner, Arias-Vasquez, Schenck, van der Voet, Franke), Department of Psychiatry (Mota, Arias-Vasquez, Franke), and Department for Health Evidence (Kiemeney), Radboud University Medical Center and Donders Institute for Brain, Cognition, and Behavior, Nijmegen, the Netherlands; Department of Biomedicine and Center for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark (Demontis, Børglum); and Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark (Demontis, Børglum).
Radboud University Nijmegen · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAttention deficit hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with intellectual disability, and shared overlapping genetics have been suggested. The aim of this study was to identify novel ADHD genes by investigating whether genes carrying rare mutations linked to intellectual disability contribute to ADHD risk through common genetic variants. Validation and characterization of candidates were performed using
methodsCommon genetic variants in a diagnostic gene panel of 396 autosomal intellectual disability genes were tested for association with ADHD risk through gene set and gene-wide analyses, using ADHD meta-analytic data from the Psychiatric Genomics Consortium for discovery (N=19,210) and ADHD data from the Lundbeck Foundation Initiative for Integrative Psychiatric Research for replication (N=37,076). The significant genes were functionally validated and characterized in
resultsThe intellectual disability gene set was significantly associated with ADHD risk in the discovery and replication data sets. The three genes most consistently associated were
conclusionsThis study reveals that a large set of intellectual disability-related genes contribute to ADHD risk through effects of common alleles. Utilizing this continuity, the authors identified
Indexed as
AdultAgedAnimalsAttention Deficit Disorder with Hyperactivitybeta-Galactoside alpha-2,3-SialyltransferaseCircadian RhythmDopaminergic NeuronsDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesGenome-Wide Association StudyHumansIntellectual DisabilityIntercellular Signaling Peptides and ProteinsLocomotionbeta-Galactoside alpha-2,3-Sialyltransferasebrun protein, DrosophilaDrosophila ProteinsIntercellular Signaling Peptides and ProteinsMEF2C protein, humanMef2 protein, DrosophilaMEF2 Transcription FactorsMyogenic Regulatory FactorsSialyltransferasesST3GAL3 protein, humanTRAPPC9 protein, humanADHDDrosophila melanogasterGeneticsIntellectual DisabilityMEF2CTRAPPC9
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