ArticleEuropean journal of preventive cardiology2020
Exercise intolerance and fatigue in chronic heart failure: is there a role for group III/IV afferent feedback?
Article in European journal of preventive cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Effect of a new resistance training method on the metaboreflex in cardiac rehabilitation patients: a randomized controlled trial.European journal of applied physiology · 2024Trial
- Hemodynamic Response to High- and Low-Load Resistance Exercise in Patients with Coronary Artery Disease: A Randomized, Crossover Clinical Trial.International journal of environmental research and public health · 2021Trial
- Article
- Iron Deficiency as a Modifiable Risk Factor in Heart Failure: Evidence and Recommendations.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Review
- Association between fatigue and self-care in patients with heart failure: a cross-sectional study.Revista da Escola de Enfermagem da U S P · 2026Article
- Isokinetic knee strength as a predictor of cardiorespiratory responses during loaded aerobic capacity test in elite athletes.Scientific reports · 2025Article
- Dissecting the exercise pressor reflex in heart failure: A multi-step failure.Autonomic neuroscience : basic & clinical · 2025Review
- Correlation of Sit-to-Stand Test and 6-Minute Walk Test to Illustrate Cardiorespiratory Fitness in Systolic Heart Failure Patients.Annals of rehabilitation medicine · 2025Article
- Consequences of group III/IV afferent feedback and respiratory muscle work on exercise tolerance in heart failure with reduced ejection fraction.Experimental physiology · 2023Review
- Article
- Effect of Lower Limb Venous Dilation on the Autonomic Cardiac Response among Healthy Young Men.Healthcare (Basel, Switzerland) · 2023Article
- Influence of locomotor muscle group III/IV afferents on cardiovascular and ventilatory responses in human heart failure during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- The ergoreflex: how the skeletal muscle modulates ventilation and cardiovascular function in health and disease.European journal of heart failure · 2021Review
- Article
- Response: Commentary: Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety.Frontiers in physiology · 2021Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise intolerance and early fatiguability are hallmark symptoms of chronic heart failure. While the malfunction of the heart is certainly the leading cause of chronic heart failure, the patho-physiological mechanisms of exercise intolerance in these patients are more complex, multifactorial and only partially understood. Some evidence points towards a potential role of an exaggerated afferent feedback from group III/IV muscle afferents in the genesis of these symptoms. Overactivity of feedback from these muscle afferents may cause exercise intolerance with a double action: by inducing cardiovascular dysregulation, by reducing motor output and by facilitating the development of central and peripheral fatigue during exercise. Importantly, physical inactivity appears to affect the progression of the syndrome negatively, while physical training can partially counteract this condition. In the present review, the role played by group III/IV afferent feedback in cardiovascular regulation during exercise and exercise-induced muscle fatigue of healthy people and their potential role in inducing exercise intolerance in chronic heart failure patients will be summarised.
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