Evidence map›Paper›PMID 32046448›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2020

Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States.

David S Kiss, Istvan Toth, Gergely Jocsak, Tibor Bartha, Laszlo V Frenyo, Zoltan Barany, Tamas L Horvath, Attila Zsarnovszky

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Article in Reproductive sciences (Thousand Oaks, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David S KissDepartment of Physiology and Biochemistry, University of Veterinary Medicine, Istvan u. 2, Budapest, 1078, Hungary. kiss.david@univet.hu.
Istvan TothDepartment of Physiology and Biochemistry, University of Veterinary Medicine, Istvan u. 2, Budapest, 1078, Hungary.
Gergely JocsakDepartment of Physiology and Biochemistry, University of Veterinary Medicine, Istvan u. 2, Budapest, 1078, Hungary.
Tibor BarthaDepartment of Physiology and Biochemistry, University of Veterinary Medicine, Istvan u. 2, Budapest, 1078, Hungary.
Laszlo V FrenyoDepartment of Physiology and Biochemistry, University of Veterinary Medicine, Istvan u. 2, Budapest, 1078, Hungary.
Zoltan BaranyDepartment of Physiology and Biochemistry, University of Veterinary Medicine, Istvan u. 2, Budapest, 1078, Hungary.
Tamas L HorvathDepartment of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, Szent Istvan University, Pater Karoly u. 1, Godollo, 2100, Hungary.
Attila ZsarnovszkyDepartment of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, Szent Istvan University, Pater Karoly u. 1, Godollo, 2100, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypothalamus is the main regulatory center of many homeostatic processes, such as reproduction, food intake, and sleep-wake behavior. Recent findings show that there is a strongly interdependent side-linked localization of hypothalamic functions between the left and right hemispheres. The goal of the present study was to trace functional asymmetry of the hypothalamus related to the regulation of food intake and reproduction, in male rodents. Subjects were examined through measurements of mitochondrial metabolism ex vivo. Impact of gonadectomy and scheduled feeding was tested on the modulation of hypothalamic metabolic asymmetry. Results show that in male rats, functional lateralization of the hypothalamus can be attributed to the satiety state rather than to reproductive control. Fasting caused left-sided metabolic dominance, while satiety was linked to the right hemisphere; trends and direction in sided dominance gradually followed the changes in satiety state. Our findings revealed satiety state-dependent metabolic differences between the two hypothalamic hemispheres. It is therefore concluded that, at least in male rats, the hypothalamic hemispheres control the satiety state-related functions in an asymmetric manner.

Indexed as

AnimalsCastrationFunctional LateralityHomeostasisHypothalamusMaleMitochondriaNeuronsRatsRats, WistarReproductionSatiety ResponseFeeding stateGonadectomyHypothalamic asymmetryMelanocortin systemMitochondrial metabolismRegulation of homeostasis

Identifiers

PMID32046448
PMCPMC7181557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.