Evidence map›Paper›PMID 32046185›Full record

ArticleCells2020

Astroglial Connexin 43 Deficiency Protects against LPS-Induced Neuroinflammation: A TSPO Brain µPET Study with [

Nicolas Vignal, Anne-Cécile Boulay, Carine San, Martine Cohen-Salmon, Nathalie Rizzo-Padoin, Laure Sarda-Mantel, Xavier Declèves, Salvatore Cisternino, Benoît Hosten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Nicolas VignalUniversité de Paris, Faculté de Santé, Institut de Recherche Saint-Louis, Unité Claude Kellershohn, 75010 Paris, France.
Anne-Cécile BoulayCenter for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, PSL Research University, 75005 Paris, France.
Carine SanAssistance Publique - Hôpitaux de Paris, Hôpital Saint-Louis: Service Pharmacie, Unité Claude Kellershohn, 75010 Paris, France.
Martine Cohen-SalmonCenter for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, PSL Research University, 75005 Paris, France.
Nathalie Rizzo-PadoinUniversité de Paris, Faculté de Santé, Institut de Recherche Saint-Louis, Unité Claude Kellershohn, 75010 Paris, France.
Laure Sarda-MantelUniversité de Paris, Faculté de Santé, Institut de Recherche Saint-Louis, Unité Claude Kellershohn, 75010 Paris, France.
Xavier DeclèvesINSERM UMR-S 1144, Therapeutic Optimisation in Neuropsychopharmacology, 75005 Paris, France.
Salvatore CisterninoINSERM UMR-S 1144, Therapeutic Optimisation in Neuropsychopharmacology, 75005 Paris, France.
Benoît HostenUniversité de Paris, Faculté de Santé, Institut de Recherche Saint-Louis, Unité Claude Kellershohn, 75010 Paris, France.
Inserm · FRCentre National de la Recherche Scientifique · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Necker-Enfants Malades · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astroglial connexin 43 (Cx43) has been recognized as a crucial immunoregulating factor in the brain. Its inactivation leads to a continuous immune recruitment, cytokine expression modification and a specific humoral autoimmune response against the astrocytic extracellular matrix but without brain lesions or cell lysis. To assess the impact of Cx43 deletion on the brain's inflammatory response, TSPO expression was studied by positron emission tomography (PET) imaging with a specific radioligand, [

Indexed as

Positron-Emission TomographyAnilidesAnimalsArea Under CurveAstrocytesBrainCerebral CortexConnexin 43FemaleInflammationLipopolysaccharidesMaleMice, Inbred C57BLMice, KnockoutPositron Emission Tomography Computed TomographyPyridinesAnilidesBzrp protein, mouseConnexin 43LipopolysaccharidesN-(2-((N-(4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl fluoridePyridinesReceptors, GABA[18F]FEPPAastrocytesautoimmunityblood–brain barrierbrain inflammationConnexin 43PET imagingTSPO

Identifiers

PMID32046185
PMCPMC7072124
OpenAlexW3005296014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.