Evidence map›Paper›PMID 32046118›Full record

ArticleCells2020

WNT5a-ROR Signaling Is Essential for Alveologenesis.

Changgong Li, Susan M Smith, Neil Peinado, Feng Gao, Wei Li, Matt K Lee, Beiyun Zhou, Saverio Bellusci, Gloria S Pryhuber, Hsin-Yi Henry Ho and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Hedgehog and Platelet-derived Growth Factor Signaling Intersect during Postnatal Lung Development.American journal of respiratory cell and molecular biology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Changgong LiDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Susan M SmithDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Neil PeinadoDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Feng GaoDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Wei LiDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Matt K LeeDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Beiyun ZhouHastings Center for Pulmonary Research and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA 90033, USA.
Saverio BellusciDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
Gloria S PryhuberDivision of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Hsin-Yi Henry HoDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616, USA.
Zea BorokHastings Center for Pulmonary Research and Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA 90033, USA.
Parviz MinooDivision of Neonatology, Departments of Pediatrics, LAC+USC Medical Center and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA.
LAC+USC Medical Center · USHastings Center · USUniversity of California, Davis · USUniversity of Rochester Medical Center · US

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
Beyond the Barrier: Alveolar Epithelial Cell Biology in Health and DiseaseR35HL135747 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BOROK, ZEA · 2017 to 2023
$6.8M
Role of Chaperone GRP78 and Mitochondrial Dysfunction in ER Stress-Mediated Pulmonary FibrosisR01HL114959 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANN, DAVID K., ZHOU, BEIYUN · 2013 to 2025
$4.2M
Postnatal Alveolar FormationR01HL143059 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MINOO, PARVIZ MINOO · 2018 to 2021
$2.1M
WNT5a Signaling in Stage Specific Alveolar Epithelial Cell DifferentiationR01HL144932 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LI, CHANGGONG, MINOO, PARVIZ MINOO · 2019 to 2022
$2.0M
Deciphering Wnt-Ror signaling in cytoskeletal regulation and tissue shape controlR35GM119574 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HO, HSIN-YI HENRY · 2016 to 2021
$2.0M
NCATS NIH HHS UL1 TR002001NHLBI NIH HHS R01 HL114959NHLBI NIH HHS R01 HL143059NHLBI NIH HHS R01 HL144932NHLBI NIH HHS R35 HL135747NIGMS NIH HHS R35 GM119574
6 · The paper itself

Abstract

WNT5a is a mainly "non-canonical" WNT ligand whose dysregulation is observed in lung diseases such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma. Germline deletion of Wnt5a disrupts embryonic lung development. However, the temporal-specific function of WNT5a remains unknown. In this study, we generated a conditional loss-of-function mouse model (Wnt5a

Indexed as

OrganogenesisSignal TransductionAnimalsAnimals, NewbornCell DifferentiationCell MovementCells, CulturedEndothelial CellsGene Expression Regulation, DevelopmentalHumansInfant, NewbornMiceModels, BiologicalMyofibroblastsPulmonary AlveoliReceptor Tyrosine Kinase-like Orphan ReceptorsReceptor Tyrosine Kinase-like Orphan ReceptorsROR1 protein, humanRor1 protein, mouseROR2 protein, humanRor2 protein, mouseWnt-5a ProteinalveologenesislungmigrationRORsecondary crest myofibroblastWNT5a

Identifiers

PMID32046118
PMCPMC7072327
OpenAlexW3004683268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.