3D Textural, Morphological and Statistical Analysis of Voxel of Interests in 3T MRI Scans for the Detection of Parkinson's Disease Using Artificial Neural Networks.

Parkinson's disease is caused due to the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Presently, with the exponential growth of the aging population across the world the number of people being affected by the disease is also increasing and it imposes a huge economic burden on the governments. However, to date, no therapy or treatment has been found that can completely eradicate the disease. Therefore, early detection of Parkinson's disease is very important so that the progressive loss of dopaminergic neurons can be controlled to provide the patients with a better life. In this study, 3T T1-MRI scans were collected from 906 subjects, out of which, 203 are control subjects, 66 are prodromal subjects and 637 are Parkinson's disease patients. To analyze the MRI scans for the detection of neurodegeneration and Parkinson's disease, eight subcortical structures were segmented from the acquired MRI scans using atlas based segmentation. Further, on the extracted eight subcortical structures, feature extraction was performed to extract textural, morphological and statistical features, respectively. After the feature extraction process, an exhaustive set of 107 features were generated for each MRI scan. Therefore, a two-level feature extraction process was implemented for finding the best possible feature set for the detection of Parkinson's disease. The two-level feature extraction procedure leveraged correlation analysis and recursive feature elimination, which at the end provided us with 20 best performing features out of the extracted 107 features. Further, all the features were trained using machine learning algorithms and a comparative analysis was performed between four different machine learning algorithms based on the selected performance metrics. And at the end, it was observed that artificial neural network (multi-layer perceptron) performed the best by providing an overall accuracy of 95.3%, overall recall of 95.41%, overall precision of 97.28% and f1-score of 94%, respectively.