Evidence map›Paper›PMID 32046042›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator.

Marina Sánchez-Hidalgo, Jesús Martín, Olga Genilloud

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Lasso Peptides-A New Weapon Against Superbugs.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Lasso peptides: A focus on therapeutic index.World journal of microbiology & biotechnology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. How to harness biosynthetic gene clusters of lasso peptides.Journal of industrial microbiology & biotechnology · 2020
    Review
  11. Lasso Peptides: Heterologous Production and Potential Medical Application.Frontiers in bioengineering and biotechnology · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marina Sánchez-HidalgoFundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain.
Jesús MartínFundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain.
Olga GenilloudFundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humidimycin (MDN-0010) is a ribosomally synthesized and post-translationally modified peptide (RiPP) belonging to class I lasso peptides, and is structurally related to siamycins, which have been shown to have strong antimicrobial activities against Gram-positive bacteria and to possess anti-HIV activity. Humidimycin was isolated from the strain

Indexed as

biosynthetic gene clustergenome miningGibson assemblyheterologous expressionHumidimycinlasso peptideMDN-0010RiPPStreptomyces humidus

Identifiers

PMID32046042
PMCPMC7168211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.