ArticleNeuroImage2020
Cortical functional connectivity indexes arousal state during sleep and anesthesia.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Intranasal low-dose dexmedetomidine alleviates propofol-associated postoperative sleep disturbance in female hysteroscopy patients: a randomized controlled trial.BMC anesthesiology · 2026Trial
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- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants.British journal of anaesthesia · 2026Article
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- EEG Connectivity is an Objective Signature of Reduced Consciousness and Sleep Depth.Brain topography · 2025Article
- Article
- Modulation of Auditory Novelty Processing by Dexmedetomidine and Natural Sleep: A Human Intracranial Electrophysiology Study.The European journal of neuroscience · 2025Article
- Temporal dynamics of offline transcranial ultrasound stimulation.Current research in neurobiology · 2025Article
- The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Clinical and intracranial electrophysiological signatures of post-operative and post-ictal delirium.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- Assessing expert reliability in determining intracranial EEG channel quality and introducing the automated bad channel detection algorithm.Journal of neural engineering · 2024Article
- Article
- Globus pallidus externus drives increase in network-wide alpha power with propofol-induced loss-of-consciousness in humans.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Research on Brain Networks of Human Balance Based on Phase Estimation Synchronization.Brain sciences · 2024Article
- Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia.CNS neuroscience & therapeutics · 2024Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness.British journal of anaesthesia · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Disruption of cortical connectivity likely contributes to loss of consciousness (LOC) during both sleep and general anesthesia, but the degree of overlap in the underlying mechanisms is unclear. Both sleep and anesthesia comprise states of varying levels of arousal and consciousness, including states of largely maintained conscious experience (sleep: N1, REM; anesthesia: sedated but responsive) as well as states of substantially reduced conscious experience (sleep: N2/N3; anesthesia: unresponsive). Here, we tested the hypotheses that (1) cortical connectivity will exhibit clear changes when transitioning into states of reduced consciousness, and (2) these changes will be similar for arousal states of comparable levels of consciousness during sleep and anesthesia. Using intracranial recordings from five adult neurosurgical patients, we compared resting state cortical functional connectivity (as measured by weighted phase lag index, wPLI) in the same subjects across arousal states during natural sleep [wake (WS), N1, N2, N3, REM] and propofol anesthesia [pre-drug wake (WA), sedated/responsive (S), and unresponsive (U)]. Analysis of alpha-band connectivity indicated a transition boundary distinguishing states of maintained and reduced conscious experience in both sleep and anesthesia. In wake states WS and WA, alpha-band wPLI within the temporal lobe was dominant. This pattern was largely unchanged in N1, REM, and S. Transitions into states of reduced consciousness N2, N3, and U were characterized by dramatic changes in connectivity, with dominant connections shifting to prefrontal cortex. Secondary analyses indicated similarities in reorganization of cortical connectivity in sleep and anesthesia. Shifts from temporal to frontal cortical connectivity may reflect impaired sensory processing in states of reduced consciousness. The data indicate that functional connectivity can serve as a biomarker of arousal state and suggest common mechanisms of LOC in sleep and anesthesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.