ArticleJournal of obesity & metabolic syndrome2020
Three-Month Daily Consumption of Sugar-Sweetened Beverages Affects the Liver, Adipose Tissue, and Glucose Metabolism.
Article in Journal of obesity & metabolic syndrome, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The impact of high fructose corn syrup on liver injury and glucose metabolism: a systematic review.Frontiers in nutrition · 2025Pooled it
- Efficacy and Safety ofFrontiers in endocrinology · 2021Trial
- Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study.Endocrinology and metabolism (Seoul, Korea) · 2020Trial
- Trends in Dairy and Sugar-Sweetened Beverage Consumption among Korean Young Adults Aged 19-29 Years: Analysis of Korea National Health and Nutrition Examination Survey 2010-2021.Journal of obesity & metabolic syndrome · 2026Article
- Cold exposure and human metabolism: A heterogeneous response across tissues and organs.Temperature (Austin, Tex.) · 2026Review
- Association of sugary beverages consumption with liver fat content and fibro-inflammation: a large cohort study.Frontiers in public health · 2025Article
- Long-Term Memory Function Impairments following Sucrose Exposure in Juvenile versus Adult Rats.Biomedicines · 2022Article
- Current WHO recommendation to reduce free sugar intake from all sources to below 10% of daily energy intake for supporting overall health is not well supported by available evidence.The American journal of clinical nutrition · 2022Review
- Association between Body Mass Index with Sugar-Sweetened and Dairy Beverages Consumption in Children from the Mexico-USA Border.International journal of environmental research and public health · 2022Article
- Effect of lifelong sucrose consumption at human-relevant levels on food intake and body composition of C57BL/6N mice.Frontiers in nutrition · 2022Article
- Effects of chronic bubble tea administration on behavior and cognition in C57BL/6 mice.Frontiers in psychiatry · 2022Article
- Are fat and sugar just as detrimental in old age?GeroScience · 2021Review
- Review
- Effects of High White and Brown Sugar Consumption on Serum Level of Brain-Derived Neurotrophic Factor, Insulin Resistance, and Body Weight in Albino Rats.Journal of obesity & metabolic syndrome · 2020Article
- Collateral Damage of the COVID-19 Pandemic on Nutritional Quality and Physical Activity: Perspective from South Korea.Obesity (Silver Spring, Md.) · 2020Article
- Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing evidence suggests links between sugar-sweetened beverages (SSBs) and metabolic disorders. We investigated the effects of SSBs commonly consumed by adolescents and their relationships to glucose metabolism and fatty liver.
methodsWe treated 7-week old male C57BL/6 mice with water (control) or one of three different SSBs, carbonated soda (Coca-Cola), sweetened milk coffee (Maxwell), or chocolate-added cocoa (Choco-Latte), for 13 weeks (n=10 in each group). Half of the animals were fed a regular chow diet and the other half a high-fat diet (40% fat). Body composition and biochemical variables were investigated at the end of treatment. Histology of the liver and adipose tissue, as well as molecular signaling related to glucose and lipid metabolism, were also evaluated.
resultsDuring the 13-week treatment, mice treated with chocolate-added cocoa or sweetened milk coffee showed significantly greater increases in body weight compared with controls, especially when fed a high-fat diet. Fasting glucose level was higher in the three SSB-treated groups compared with the control group. Lipid droplets in the liver, fat cell size, and number of CD68-positive cells in adipose tissue were greater in the SSB-treated groups than in the control group. SSB treatments increased the expression of genes related to inflammatory processes in the liver and adipose tissue. Phosphorylation of AKT and glycogen synthase kinase in muscle was significantly reduced in SSB-treated groups.
conclusionDaily consumption of SSBs over 3 months lead to metabolic impairment and weight gain and may contribute to development of metabolic diseases.
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Registered trials
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