Evidence map›Paper›PMID 32045262›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2020

Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking.

Maria Ibars, Matthew T Maier, Ernie Yulyaningsih, Luz Perez, Rachel Cheang, Anna Vilhelmsson, Sharon M Louie, Scott A Wegner, Xiaoyi Yuan, Holger K Eltzschig and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Maria IbarsDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Matthew T MaierDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Ernie YulyaningsihDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Luz PerezDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Rachel CheangDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Anna VilhelmssonDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Sharon M LouieDepartments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkeley, California.
Scott A WegnerDepartment of Neurology, Department of Anatomy, University of California, San Francisco, California.
Xiaoyi YuanDepartment of Anesthesiology, University of Texas Health Science Center at Houston, Houston, Texas.
Holger K EltzschigDepartment of Anesthesiology, University of Texas Health Science Center at Houston, Houston, Texas.
Frederic W HopfDepartment of Neurology, Department of Anatomy, University of California, San Francisco, California.
Daniel K NomuraDepartments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkeley, California.
Suneil K KoliwadDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
Allison W XuDiabetes Center, Department of Anatomy, University of California, San Francisco, California.
University of California, San Francisco · USThe University of Texas Health Science Center at Houston · USUniversity of California, Berkeley · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Mouse Metabolic Phenotyping Center (MMPC) at UC DavisU2CDK092993 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2016 to 2021
$5.9M
Novel Immunologic Effects of Semaphorin 7a in IPFR01HL109233 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2011 to 2019
$3.7M
A brain-liver circuit in regulation of alcoholic liver diseaseR01AA022665 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XU, ALLISON W · 2014 to 2018
$2.0M
Hypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury.R01DK109574 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2016 to 2019
$1.8M
Targeting MicroRNA miR-122 for the Treatment of Perioperative Liver InjuryR01DK122796 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K., JU, CYNTHIA · 2020 to 2023
$1.8M
Microglia: dietary fat-sensitive mediators of inflammation and metabolic diseaseR01DK103175 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOLIWAD, SUNEIL KRISHNA · 2015 to 2019
$1.8M
Proton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7M
Amphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5M
NCRR NIH HHS M01 RR001271NHLBI NIH HHS R01 HL109233NHLBI NIH HHS R01 HL119837NHLBI NIH HHS R01 HL133900NIAAA NIH HHS R01 AA022665NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK097075NIDDK NIH HHS R01 DK103175NIDDK NIH HHS R01 DK109574NIDDK NIH HHS R01 DK122796NIDDK NIH HHS U2C DK092993
6 · The paper itself

Abstract

Excessive alcohol consumption, including binge drinking, is a common cause of fatty liver disease. Binge drinking rapidly induces hepatic steatosis, an early step in the pathogenesis of chronic liver injury. Despite its prevalence, the process by which excessive alcohol consumption promotes hepatic lipid accumulation remains unclear. Alcohol exerts potent effects on the brain, including hypothalamic neurons crucial for metabolic regulation. However, whether or not the brain plays a role in alcohol-induced hepatic steatosis is unknown. In the brain, alcohol increases extracellular levels of adenosine, a potent neuromodulator, and previous work implicates adenosine signaling as being important for the development of alcoholic fatty liver disease. Acute alcohol exposure also increases both the activity of agouti-related protein (AgRP)-expressing neurons and AgRP immunoreactivity. Here, we show that adenosine receptor A

Indexed as

Agouti-Related ProteinAnimalsBinge DrinkingFatty Liver, AlcoholicHypothalamusLipid MetabolismLiverMaleMiceNeuronsAgouti-Related ProteinAgrp protein, mouseadenosine signalingAgRPalcoholbinge drinkinghepatic steatosis

Identifiers

PMID32045262
PMCPMC7272724
OpenAlexW3005841465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.