ArticleOrganic letters2020
Synthesis of Enantioenriched α-Deuterated α-Amino Acids Enabled by an Organophotocatalytic Radical Approach.
Article in Organic letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Visible Light-Mediated Direct Decarboxylative Giese Amidations without a Photocatalyst─Batch and Flow.The Journal of organic chemistry · 2026Article
- Article
- Site-Selective Deuteration of α-Amino Esters with 2-Hydroxynicotinaldehyde as a Catalyst.ACS omega · 2024Article
- Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni-Electrocatalytic Decarboxylative Arylation.Journal of the American Chemical Society · 2024Article
- Direct decarboxylative Giese amidations: photocatalyticChemical science · 2023Article
- Visible-light acridinium-based organophotoredox catalysis in late-stage synthetic applications.RSC advances · 2023Review
- Palladium-Catalyzed C2-Selective Oxidative Olefination of Benzo[ACS omega · 2023Article
- A Vitamin BAngewandte Chemie (International ed. in English) · 2022Article
- A Vitamin BAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Article
- Towards Enantiomerically Pure Unnatural α-Amino Acids via Photoredox Catalytic 1,4-Additions to a Chiral Dehydroalanine.The Journal of organic chemistry · 2022Article
- Exploiting photoredox catalysis for carbohydrate modification through C-H and C-C bond activation.Nature reviews. Chemistry · 2022Review
- Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK.RSC chemical biology · 2022Article
- Visible-light mediated catalytic asymmetric radical deuteration at non-benzylic positions.Nature communications · 2022Article
- carba-Nucleopeptides (cNPs): A Biopharmaceutical Modality Formed through Aqueous Rhodamine B Photoredox Catalysis.Angewandte Chemie (International ed. in English) · 2022Article
- Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives.Chemical science · 2022Article
- Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles.Nature communications · 2021Article
- Combining flavin photocatalysis with parallel synthesis: a general platform to optimize peptides with non-proteinogenic amino acids.Chemical science · 2021Article
- Radical-Based Synthesis and Modification of Amino Acids.Angewandte Chemie (International ed. in English) · 2021Review
- Direct, stereoselective thioglycosylation enabled by an organophotoredox radical strategy.Chemical science · 2020Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
A mild, versatile organophotoredox protocol has been developed for the preparation of diverse, enantioenriched α-deuterated α-amino acids. Distinct from the well-established two-electron transformations, this radical-based strategy offers the unrivaled capacity of the convergent unification of readily accessible feedstock carboxylic acids and a chiral methyleneoxazolidinone fragment and the simultaneous highly diastereo-, chemo-, and regioselective incorporation of deuterium. Furthermore, the approach has addressed the long-standing challenge of the installation of sterically demanding side chains into α-amino acids.
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