Evidence map›Paper›PMID 32045203›Full record

ArticleACS chemical biology2020

A Fluorescent Teixobactin Analogue.

Michael A Morris, Melody Malek, Mohammad H Hashemian, Betty T Nguyen, Sylvie Manuse, Kim Lewis, James S Nowick

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents.International journal of molecular sciences · 2024
    Article
  3. New Teixobactin Analogues with a Total Lactam Ring.ACS medicinal chemistry letters · 2023
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael A MorrisDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0003-4526-271X
Melody MalekDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Mohammad H HashemianDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Betty T NguyenDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Sylvie ManuseAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Kim LewisAntimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts 02115, United States.
James S NowickDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0002-2273-1029
University of California, Irvine · USNortheastern University · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Development of Teixobactin AnaloguesR56AI137258 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2018 to 2018
$444k
NCI NIH HHS P30 CA062203NIAID NIH HHS R56 AI137258NIGMS NIH HHS P50 GM076516
6 · The paper itself

Abstract

This report describes the first synthesis and application of a fluorescent teixobactin analogue that exhibits antibiotic activity and binds to the cell walls of Gram-positive bacteria. The teixobactin analogue, Lys(Rhod)

Indexed as

AlanineAmino Acid SequenceAnti-Bacterial AgentsBoron CompoundsCatalytic DomainCell WallCyclizationDepsipeptidesDose-Response Relationship, DrugDrug DiscoveryEsterificationFluorescent DyesGram-Positive BacteriaMicrobial Sensitivity TestsOptical ImagingPyrrolidines4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAlanineAnti-Bacterial AgentsBoron CompoundsDepsipeptidesFluorescent DyesL-allo-enduracididinePyrrolidinesteixobactinVancomycin

Identifiers

PMID32045203
PMCPMC7814985
OpenAlexW3005913631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.