Evidence map›Paper›PMID 32045053›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2020

From Shape to Function: The Next Step in Bioprinting.

Riccardo Levato, Tomasz Jungst, Ruben G Scheuring, Torsten Blunk, Juergen Groll, Jos Malda

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Discrete 2D Material Programming for 3D Shaping and Morphogenesis-Inspired 4D Bioprinting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
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  10. Thiolated Polymers in 3D Bioprinting: Control of Gelation.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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  16. Article
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  18. Article
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  20. Article

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Riccardo LevatoDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, 3584 CX, Utrecht, The Netherlands.
Tomasz JungstDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.ORCID https://orcid.org/0000-0002-2458-8713
Ruben G ScheuringDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Torsten BlunkDepartment of Trauma, Hand, Plastic and Reconstructive Surgery, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Juergen GrollDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Jos MaldaDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, 3584 CX, Utrecht, The Netherlands.

Funding

Collaborative Research Center 326998133-TRR 225Collaborative Research Center SFB/TRR 225Deutsche ForschungsgemeinschaftERC 617989European Research Council 3DJOINTEuropean Research Council 617989European Research Council 647426Horizon 2020 Research and Innovation Program 814444Netherlands Organization for Scientific Research 024.003.013ReumaNederland LLP-12ReumaNederland LLP-22
6 · The paper itself

Abstract

In 2013, the "biofabrication window" was introduced to reflect the processing challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable materials that could serve as cell-laden bioinks, as well as the limitations of printing and assembly methods, presented a major constraint. However, recent developments have now resulted in the availability of a plethora of bioinks, new printing approaches, and the technological advancement of established techniques. Nevertheless, it remains largely unknown which materials and technical parameters are essential for the fabrication of intrinsically hierarchical cell-material constructs that truly mimic biologically functional tissue. In order to achieve this, it is urged that the field now shift its focus from materials and technologies toward the biological development of the resulting constructs. Therefore, herein, the recent material and technological advances since the introduction of the biofabrication window are briefly summarized, i.e., approaches how to generate shape, to then focus the discussion on how to acquire the biological function within this context. In particular, a vision of how biological function can evolve from the possibility to determine shape is outlined.

Indexed as

Biocompatible MaterialsBioprintingGelatinGelsHumansMicrofluidicsNanocompositesPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsBiocompatible MaterialsGelatinGelsbiofabricationbioinksbiological functionregenerative medicinetissue hierarchy

Identifiers

PMID32045053
PMCPMC7116209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.