ArticleNeuroImage2020
Frontoparietal theta-gamma interactions track working memory enhancement with training and tDCS.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Trial
- Frontoparietal Brain Network Plays a Crucial Role in Working Memory Capacity during Complex Cognitive Task.eNeuro · 2024Trial
- Theta tACS impairs episodic memory more than tDCS.Scientific reports · 2023Trial
- Individual differences in neuroanatomy and neurophysiology predict effects of transcranial alternating current stimulation.Brain stimulationTrial
- Transcranial direct current stimulation enhances cognitive performance and modulates QEEG beta- and theta-band power in patients undergoing whole-brain radiotherapy.IBRO neuroscience reports · 2026Article
- Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.Cell reports · 2026Article
- Boosting brainpower in ageing: Task-specific and transfer effects of tDCS-enhanced working memory training.Cognitive, affective & behavioral neuroscience · 2026Article
- Mapping the Digital Mind: A Meta-Analysis of EEG Biomarkers in Cognition, Emotion, and Mental Health.Brain sciences · 2026Review
- Further insights into the efficacy and moderators of transcranial alternating current stimulation for working memory.World journal of psychiatry · 2026Article
- Cognitive training for breast cancer patients with cancer-related cognitive impairment: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- The Instantaneous Effect and Its Mechanism of Transcranial Direct Current Stimulation on Working Memory Based on Delta and Gamma Band Electroencephalography Characteristics.Brain sciences · 2025Article
- The effects of amplitude modulated transcranial alternating current stimulation on working memory of college students.Frontiers in human neuroscience · 2025Article
- Individualized frequency and montage tACS to engage theta-gamma coupling and enhance working memory in mild cognitive impairment.Frontiers in psychiatry · 2025Article
- Theta power reduction and theta-gamma coupling desynchronization are associated with working memory interference and anxiety symptoms in panic disorder: a retrospective study.BMC psychiatry · 2024Article
- Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.iScience · 2024Article
- Long-range and cross-frequency neural modulation of gamma flicker on vigilance decrement.Cognitive neurodynamics · 2024Article
- Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Information-based rhythmic transcranial magnetic stimulation to accelerate learning during auditory working memory training: a proof-of-concept study.Frontiers in neuroscience · 2024Article
- Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories.Frontiers in computational neuroscience · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Despite considerable interest in enhancing, preserving, and rehabilitating working memory (WM), efforts to elicit sustained behavioral improvements have been met with limited success. Here, we paired WM training with transcranial direct current stimulation (tDCS) to the frontoparietal network over four days. Active tDCS enhanced WM performance by modulating interactions between frontoparietal theta oscillations and gamma activity, as measured by pre- and post-training high-density electroencephalography (EEG). Increased phase-amplitude coupling (PAC) between the prefrontal stimulation site and temporo-parietal gamma activity explained behavioral improvements, and was most effective when gamma occurred near the prefrontal theta peak. These results demonstrate for the first time that tDCS-linked WM training elicits lasting changes in behavior by optimizing the oscillatory substrates of prefrontal control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.