ArticleJournal of cardiothoracic and vascular anesthesia2020
Intraoperative Plasma Transfusion Volumes and Outcomes in Cardiac Surgery.
Article in Journal of cardiothoracic and vascular anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Mathematical modeling of flow-mediated thrombin generation after treatment of postoperative bleeding in cardiac surgery with cardiopulmonary bypass.Journal of thrombosis and haemostasis : JTH · 2026Article
- A Novel Approach to Assessing In-Hospital Mortality After On-Pump Aortic Valve Replacement.Life (Basel, Switzerland) · 2025Article
- Review
- Development and Validation of a Novel Nomogram Risk Prediction Model for In-Hospital Death Following Extended Aortic Arch Repair for Acute Type A Aortic Dissection.Reviews in cardiovascular medicine · 2025Article
- Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices.Critical care explorations · 2023Article
- Association between perioperative plasma transfusion and in-hospital mortality in patients undergoing surgeries without massive transfusion: A nationwide retrospective cohort study.Frontiers in medicine · 2023Article
- The Predictive Role of Intraoperative Blood Transfusion Components in the Prognosis of Heart Transplantation.Frontiers in cardiovascular medicine · 2022Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveAssess outcomes after intraoperative plasma transfusion in patients undergoing cardiac surgery.
designRetrospective study of adult cardiac surgical between 2011 and 2015. Relationships between plasma transfusion volume, coagulation test values, and a primary outcome of early postoperative red blood cell (RBC) transfusion were assessed via multivariable regression analyses. Secondary outcomes included hospital mortality, intensive care unit and hospital-free days, intraoperative RBCs, estimated blood loss, and reoperation for bleeding.
settingAcademic tertiary referral center.
participantsA total of 1,794 patients received intraoperative plasma transfusions during the study period.
interventionsNone. MEASUREMENTS AND MAIN
resultsHigher plasma transfusion volumes were associated with worse clinical outcomes, with each 1-unit increase being associated with greater odds for postoperative RBCs [odds ratio (OR) 1.12 (confidence interval [CI] 1.04-1.20); p = 0.002], intraoperative [OR 1.85 (CI 1.69-2.03); p < 0.001], and fewer hospital-free days [mean -0.20 (-0.39, -0.01); p = 0.04]. Each 0.1 increase in pretransfusion International Normalized Ratio (INR) was associated with increased odds of postoperative and intraoperative RBCs, reoperation for bleeding, and fewer intensive care unit and hospital-free days. For given plasma volumes, patients achieving greater reduction in elevated pretransfusion INR values experienced more favorable outcomes.
conclusionsIn patients undergoing cardiac surgery who received intraoperative plasma transfusion, higher plasma transfusion volumes were associated with inferior clinical outcomes. Higher pretransfusion INR values also were associated with worse outcomes; however, those achieving a greater degree of INR correction after plasma transfusion demonstrated more favorable outcomes. Prospective studies related to plasma transfusion are needed to address this important topic.
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