ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2020
Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis.
Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Poststroke Cognitive Impairment and the Risk of Recurrent Stroke and Mortality: Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2024Pooled it
- Pooled it
- Correlation Between Serum TGF-β1 Levels, Intracranial Atherosclerotic Plaque Parameters and Post-Stroke Cognitive Impairment.International journal of general medicine · 2026Article
- The Risk of Atrial Fibrillation and Previous Ischemic Stroke in Cognitive Decline.Journal of clinical medicine · 2024Article
- Risk factors and predictive markers of post-stroke cognitive decline-A mini review.Frontiers in aging neuroscience · 2024Review
- Higher soluble TREM-1 levels are associated with cognitive impairment after acute ischemic stroke.Frontiers in aging neuroscience · 2024Article
- Post-stroke cognitive impairment and the risk of stroke recurrence and death in patients with insulin resistance.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Article
- Impairment of attention network function in posterior circulation ischemia-evidence from the Attention Network Test.Frontiers in human neuroscience · 2022Article
- The montreal cognitive assessment and mini-mental state examination visuoexecutive subtests in acute ischemic stroke patients and their correlations with demographic and clinical factors.Acta neurologica Belgica · 2021Article
- Elevated Serum Amyloid A Is Associated With Cognitive Impairment in Ischemic Stroke Patients.Frontiers in neurology · 2021Article
- Precision Medicine for Intracranial Atherosclerotic Disease.Frontiers in neurology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 9 institutions in 2 countries.
Funding
Abstract
background and purposeCognitive impairment occurs in 20%-40% of stroke patients and is a predictor of long-term morbidity and mortality. In this study, we aim to determine the association between poststroke cognitive impairment and stroke recurrence risk, in patients with anterior versus posterior circulation intracranial stenosis.
methodsThis is a post-hoc analysis of the Stenting and Aggressive Medical Therapy for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial. The primary predictor was poststroke cognitive function measured by Montreal Cognitive Assessment (MOCA) at 3-6 months and the primary outcome was recurrent ischemic stroke. We used univariate and multivariable cox-regression models to determine the associations between MOCA at 3-6 months and recurrent stroke.
resultsOf the 451 patients enrolled in SAMMPRIS, 393 patients met the inclusion criteria. The mean age of the sample (in years) was 59.5 ± 11.3, 62.6% (246 of 393) were men. Fifty patients (12.7%) had recurrent ischemic stroke during a mean follow up of 2.7 years. The 3-6 month MOCA score was performed on 351 patients. In prespecified multivariable models, there was an association between 3 and 6 month MOCA and recurrent stroke (hazard ratio [HR] per point increase .93 95% confidence interval [CI] .88-.99, P = .040). This effect was present in anterior circulation stenosis (adjusted HR per point increase .92 95% CI .85-0.99, P = .022) but not in posterior circulation artery stenosis (adjusted HR per point increase 1.00 95% .86-1.16, P = .983).
conclusionsOverall, we found weak associations and trends between MoCA at 3-6 months and stroke recurrence but more notable and stronger associations in certain subgroups. Since our study is underpowered, larger studies are needed to validate our findings and determine the mechanism(s) behind this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.