ArticleeLife2020
Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Optical Fiber-Based Recording of Climbing Fiber CaBiology · 2022Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive NetworkFrontiers in cellular neuroscience · 2022Article
- Cerebellar complex spikes multiplex complementary behavioral information.PLoS biology · 2021Article
- Selective Antagonism of A1 Adenosinergic Receptors Strengthens the Neuromodulation of the Sensorimotor Network During Epidural Spinal Stimulation.Frontiers in systems neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The electrical connectivity in the inferior olive (IO) nucleus plays an important role in generating well-timed spiking activity. Here we combined electrophysiological and computational approaches to assess the functional organization of the IO nucleus in mice. Spontaneous fast and slow subthreshold events were commonly encountered during in vitro recordings. We show that whereas the fast events represent intrinsic regenerative activity, the slow events reflect the electrical connectivity between neurons ('spikelets'). Recordings from cell pairs revealed the synchronized occurrence of distinct groups of spikelets; their rate and distribution enabled an accurate estimation of the number of connected cells and is suggestive of a clustered organization. This study thus provides a new perspective on the functional and structural organization of the olivary nucleus and a novel experimental and theoretical approach to study electrically coupled networks.
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Registered trials
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