Evidence map›Paper›PMID 32043971›Full record

ArticleeLife2020

The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress.

Marco Fumasoni, Andrew W Murray

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Genome sequence assembly and annotation ofNAR genomics and bioinformatics · 2025
    Article
  5. Machine Learning-Based Characterization ofPathogens (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Experimental evolution for cell biology.Trends in cell biology · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Evolutionary stalling and a limit on the power of natural selection to improve a cellular module.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marco FumasoniDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.ORCID 0000-0002-4507-7824
Andrew W MurrayDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.ORCID 0000-0002-0868-6604
Harvard University · US

Funding

FEEDBACK CONTROL OF THE CELL CYCLER01GM043987 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MURRAY, ANDREW W · 1990 to 2023
$6.4M
Associazione Italiana per la Ricerca sul Cancro iCARE 17957European Molecular Biology Organization ALTF 485-2015Fondazione AIRC per la ricerca sul cancro iCARE 17957Human Frontier Science Program LT000786/2016-LNational Science Foundation #1764269NIGMS NIH HHS R01 GM043987NIGMS NIH HHS RO1-GM43987NSF-Simons Center for Mathematical and Statistical Analysis of Biology at Harvard #1764269Simons Foundation #594596
6 · The paper itself

Abstract

Many biological features are conserved and thus considered to be resistant to evolutionary change. While rapid genetic adaptation following the removal of conserved genes has been observed, we often lack a mechanistic understanding of how adaptation happens. We used the budding yeast,

Indexed as

Adaptation, BiologicalBiological EvolutionDNA ReplicationCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosomesCohesinsDNADNA-Binding ProteinsDNA DamageEpistasis, GeneticGene AmplificationMutationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStress, PhysiologicalCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsCTF4 protein, S cerevisiaeDNADNA-Binding ProteinsSaccharomyces cerevisiae Proteinscell cycle checkpointschromosome segregationDNA replicationevolutionary biologyevolvabilityexperimental evolutiongeneticsgenome evolutiongenomicsS. cerevisiae

Identifiers

PMID32043971
PMCPMC7069727
OpenAlexW3005868990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.