ArticleThe journal of spinal cord medicine2021
High tidal volume ventilation is associated with ventilator-associated pneumonia in acute cervical spinal cord injury.
Article in The journal of spinal cord medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04912583 (Comparison of Mechanical Ventilation With Low and High Tidal Volumes in Acute Spinal Cord Injury), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Mechanical Ventilation With Low and High Tidal Volumes in Acute Spinal Cord Injury: A Pilot Randomized Comparative Effectiveness Trial
Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Ultrasound monitoring respiratory muscle rehabilitation training can promote the recovery of diaphragmatic function in traumatic spinal cord injury (TSCI) patients.European journal of medical research · 2025Trial
- Factors influencing weaning success from mechanical ventilation in Emergency department patients with acute respiratory failure.American journal of translational research · 2025Article
- Plasma fibrinogen level is independent risk factor associated with the incidence of pulmonary infection in patients with spinal cord injury: a retrospective cohort study.BMC pulmonary medicine · 2024Article
- High vs. low tidal volume and pulmonary complications in patients with cervical spinal cord injury on mechanical ventilation: systematic review.Frontiers in medicine · 2024Article
- Ventilatory Strategies in Traumatic Cervical Spinal Cord Injury: Controversies and Current Updates.Asian spine journal · 2023Review
- Established and Emerging Therapies in Acute Spinal Cord Injury.Neurospine · 2022Article
- Dysphagia is associated with worse clinical outcomes in geriatric trauma patients.Trauma surgery & acute care open · 2022Article
- Systematic Review of Incidence Studies of Pneumonia in Persons with Spinal Cord Injury.Journal of clinical medicine · 2021Review
- Association of impaired levels with outcomes for cervical fracture dislocation using the Japanese diagnosis procedure combination database.Journal of craniovertebral junction & spineArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
CONTEXT/
objectivePneumonia is the leading cause of death after acute spinal cord injury (SCI). High tidal volume ventilation (HVtV) is used in SCI rehabilitation centers to overcome hypoventilation while weaning patients from the ventilator. Our objective was to determine if HVtV in the acute post-injury period in SCI patients is associated with lower incidence of ventilator-associated pneumonia (VAP) when compared to patients receiving standard tidal volume ventilation.
designCohort study.
settingRed Duke Trauma Institute, University of Texas Health Science Center at Houston, TX, USA.
participantsAdult Acute Cervical SCI Patients, 2011-2018.
interventionsHVtV. OUTCOME MEASURES: VAP, ventilator dependence at discharge, in-hospital mortality.
resultsOf 181 patients, 85 (47%) developed VAP. HVtV was utilized in 22 (12%) patients. Demographics, apart from age, were similar between patients who received HVtV and standard ventilation; patients were younger in the HVtV group. VAP developed in 68% of patients receiving HVtV and in 44% receiving standard tidal volumes (
conclusionsWhile limited by sample size and selection bias, our data revealed an association between HVtV and increased VAP. Further investigation into optimal early ventilation settings is needed for SCI patients, who are at a high risk of VAP.
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Registered trials
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