ArticleJournal of the American Chemical Society2020
Multicomponent Pyrazole Synthesis from Alkynes, Nitriles, and Titanium Imido Complexes via Oxidatively Induced N-N Bond Coupling.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- Photo-induced selective N-N bond construction via harnessing nitrene release and transfer.Nature communications · 2026Article
- Dual Excitation and Dual Emission in a 1,4-Diazepine Bearing an Extended π-System.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- 1,2-Dihydropyrimidine synthesisChemical communications (Cambridge, England) · 2025Article
- Alkyne Carboamination with Imines Catalyzed by [pyOrganometallics · 2025Article
- Article
- Recent highlights in the synthesis and biological significance of pyrazole derivatives.Heliyon · 2024Review
- Serendipitous Conversion of an Acetylamino Dideoxy-Octonic Acid Derivate into a Functionalized Carbohydrate-Pyrazole Conjugate and Investigation of the Method´s General Applicability.Molecules (Basel, Switzerland) · 2024Article
- Multicomponent Synthesis of New Fluorescent Boron Complexes Derived from 3-Hydroxy-1-phenyl-1Molecules (Basel, Switzerland) · 2024Article
- Mechanistic study of pyrazole synthesisDalton transactions (Cambridge, England : 2003) · 2024Article
- Ir(iii)/Ag(i)-catalyzed directly C-H amidation of arenes with OH-free hydroxyamides as amidating agents.RSC advances · 2024Article
- CpOrganometallics · 2023Article
- DFT Study of Regio- and Stereoselective 13DC Reaction between Diazopropane and Substituted Chalcone Derivatives: Molecular Docking of Novel Pyrazole Derivatives as Anti-Alzheimer's Agents.Molecules (Basel, Switzerland) · 2023Article
- Engendering reactivity at group 5-heteroatom multiple bondsChemical science · 2022Review
- α-Diimine synthesisChemical science · 2022Article
- Selective propargylic C(spChemical science · 2021Article
- Synthesis, Structural and Physicochemical Characterization of a Titanium(IV) Compound with the Hydroxamate LigandMolecules (Basel, Switzerland) · 2021Article
- PJournal of the American Chemical Society · 2021Article
- Ti-Catalyzed and -Mediated Oxidative Amination Reactions.Accounts of chemical research · 2021Article
- Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer's Disease and Parkinson's Disease Treatment (2011-2020).Molecules (Basel, Switzerland) · 2021Review
- Hydrazine Formation via Coupling of a Nickel(III)-NHAngewandte Chemie (International ed. in English) · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Pyrazoles are an important class of heterocycles found in a wide range of bioactive compounds and pharmaceuticals. Pyrazole synthesis often requires hydrazine or related reagents where an intact N-N bond is conservatively installed into a pyrazole precursor fragment. Herein, we report the multicomponent oxidative coupling of alkynes, nitriles, and Ti imido complexes for the synthesis of multisubstituted pyrazoles. This modular method avoids potentially hazardous reagents like hydrazine, instead forming the N-N bond in the final step via oxidation-induced coupling on Ti. The mechanism of this transformation has been studied in-depth through stoichiometric reactions of the key diazatitanacyclohexadiene intermediate, which can be accessed via multicomponent coupling of Ti imidos with nitriles and alkynes, ring opening of 2-imino-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.