Evidence map›Paper›PMID 32043488›Full record

ArticleJACC. Basic to translational science2020

Ancient Remedy for a Modern Disease: Will Celastrol Become a Treatment for Aortic Valve Stenosis?

Calvin Yeang, Sotirios Tsimikas

Abstract readEditorialComment
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Calvin YeangVascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiovascular Diseases, University of California-San Diego, La Jolla, California.
Sotirios TsimikasVascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiovascular Diseases, University of California-San Diego, La Jolla, California.

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Systems Biology Analyses for Hemodynamic Regulation of Vascular HomeostasisR01HL108735 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, SHYY, JOHN YJ · 2012 to 2024
$13.4M
Shear Regulation of MicroRNA Transportomes and Targetomes in Vascular HomeostasisR01HL106579 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, SHYY, JOHN YJ · 2011 to 2022
$8.3M
Molecular and Genetic Epidemiology of Lp(a)-mediated Calcific Aortic Valve DiseaseR01HL128550 · NHLBI · MCGILL UNIVERSITY HEALTH CTR RES INST · PI THANASSOULIS, GEORGE · 2017 to 2020
$1.7M
Pivotal Role of Oxidation-specific Epitopes in CVD and NASHR01HL148188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2019 to 2019
$551k
NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL106579NHLBI NIH HHS R01 HL108735NHLBI NIH HHS R01 HL128550NHLBI NIH HHS R01 HL148188
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antioxidantsaortic stenosisaortic valve replacementechocardiographyoxidative stressoxidized phospholipids

Identifiers

PMID32043488
PMCPMC7000881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.