ArticleThe International journal of artificial organs2020
Computational characterization of flow and blood damage potential of the new maglev CH-VAD pump versus the HVAD and HeartMate II pumps.
Article in The International journal of artificial organs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Hematologic complications and design challenges in cardiovascular devices.Communications engineering · 2026Review
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- Computational and Experimental Assessment of Shear-Induced Blood Trauma by HeartMate II, HeartMate 3, and BrioVAD.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Low Driveline Infection Rates in Patients With a Novel Fully Magnetically Levitated Ventricular Assist Device.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Key markers and detection methods for evaluating platelet dysfunction in mechanical circulatory support devices.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Comparative analysis of perioperative renal function in patients undergoing heart transplantation and left ventricular assist device implantation: a multicenter retrospective study.Journal of thoracic disease · 2025Article
- Citrate-Coated Iron Oxide Nanoparticles Facilitate Endothelialization of Left Ventricular Assist Device Impeller for Improved Antithrombogenicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Left ventricular assist devices: yesterday, today, and tomorrow.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Review
- Viscosity Modeling for Blood and Blood Analog Fluids in Narrow Gap and High Reynolds Numbers Flows.Micromachines · 2024Article
- Hemocompatibility and biophysical interface of left ventricular assist devices and total artificial hearts.Blood · 2024Review
- Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers.Micromachines · 2023Article
- Hemocompatibility and hemodynamic comparison of two centrifugal LVADs: HVAD and HeartMate3.Biomechanics and modeling in mechanobiology · 2023Article
- Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag.Medicine in novel technology and devices · 2022Article
- Development of an Ambulatory Extracorporeal Membrane Oxygenation System: From Concept to Clinical Use.Applications in engineering science · 2022Article
- A New Mathematical Numerical Model to Evaluate the Risk of Thrombosis in Three Clinical Ventricular Assist Devices.Bioengineering (Basel, Switzerland) · 2022Article
- Insights Into the Low Rate of In-Pump Thrombosis With the HeartMate 3: Does the Artificial Pulse Improve Washout?Frontiers in cardiovascular medicine · 2022Article
- Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021Article
- Equivalent Scalar Stress Formulation Taking into Account Non-Resolved Turbulent Scales.Cardiovascular engineering and technology · 2021Article
- Neutrophil injury and function alterations induced by high mechanical shear stress with short exposure time.Artificial organs · 2021Article
- Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study.Frontiers in physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Left ventricular assist devices are routinely used to treat patients with advanced heart failure as a bridge to transplant or a destination therapy. However, non-physiological shear stress generated by left ventricular assist devices damages blood cells. The continued development of novel left ventricular assist devices is essential to improve the left ventricular assist device therapy for heart failure patients. The CH-VAD is a new maglev centrifugal left ventricular assist device. In this study, the CH-VAD pump was numerically analyzed and compared with the HVAD and HeartMate II pumps under two clinically relevant conditions (flow: 4.5 L/min, pressure head: normal ~80 and hypertension ~120 mmHg). The velocity and shear stress fields, washout, and hemolysis index of the three pumps were assessed with computational fluid dynamics analysis. Under the same condition, the CH-VAD hemolysis index was two times lower than the HVAD and HeartMate II pumps; the CH-VAD had the least percentage volume with shear stress larger than 100 Pa (i.e. normal condition: 0.4% vs HVAD 1.0%, and HeartMate II 2.9%). Under the normal condition, more than 98% was washed out of the three pumps within 0.4 s. The washout times were slightly shorter under the hypertension condition for the three pumps. No regions inside the CH-VAD or HVAD had extremely long residential time, while areas near the straightener of the HeartMate II pump had long residential time (>4 s) indicating elevated risks of thrombosis. The computational fluid dynamics results suggested that the CH-VAD pump has a better hemolytic biocompatibility than the HVAD and HeartMate II pumps under the normal and hypertension conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.