Evidence map›Paper›PMID 32043313›Full record

ArticleEarly intervention in psychiatry2020

Two-year diagnostic stability in a real-world sample of individuals with early psychosis.

Philip B Cawkwell, Kirsten W Bolton, Rakesh Karmacharya, Dost Öngür, Ann K Shinn

Abstract read
In one paragraph

Article in Early intervention in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Philip B CawkwellPsychotic Disorders Division, McLean Hospital, Belmont, Massachusetts.ORCID 0000-0002-7873-1896
Kirsten W BoltonPsychotic Disorders Division, McLean Hospital, Belmont, Massachusetts.
Rakesh KarmacharyaPsychotic Disorders Division, McLean Hospital, Belmont, Massachusetts.
Dost ÖngürPsychotic Disorders Division, McLean Hospital, Belmont, Massachusetts.
Ann K ShinnPsychotic Disorders Division, McLean Hospital, Belmont, Massachusetts.

Funding

Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)P50MH115846 · NIMH · MCLEAN HOSPITAL · PI MIGUEL HERNAN · 2019 to 2026
$16.9M
Ex vivo signature of psychosis and treatment response in patient-derived neuronsR01MH113858 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI KARMACHARYA, RAKESH · 2017 to 2021
$2.7M
Fostering Research Mentorship & Training during Psychiatry Residency SupplementR25MH094612 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FAVA, MAURIZIO, GREENFIELD, SHELLY F. · 2011 to 2022
$2.3M
Auditory speech and cognitive networks in hallucinators across the psychosis spectrumK23MH100611 · NIMH · MCLEAN HOSPITAL · PI SHINN, ANN KYUNGAH · 2014 to 2018
$935k
Wnt/GSK3/beta Catenin Signaling as a Target for Treatment of Bipolar DisorderK08MH086846 · NIMH · MCLEAN HOSPITAL · PI KARMACHARYA, RAKESH · 2010 to 2014
$901k
NIMH NIH HHS K08 MH086846NIMH NIH HHS K23 MH100611NIMH NIH HHS P50 MH115846NIMH NIH HHS R01 MH113858NIMH NIH HHS R25 MH094612
6 · The paper itself

Abstract

objectivesDiagnostic shifts in first episode psychosis (FEP) are not uncommon. Many studies examining diagnostic stability use structured diagnostic interviews. Less is known about the stability of FEP diagnoses made clinically.

methodsWe conducted a retrospective chart review of patients enrolled in a transdiagnostic FEP clinic. For the 96 patients followed clinically at least 2 years, we compared diagnoses at intake and 24 months.

resultsDiagnostic stability was high for bipolar disorder (89%), schizoaffective disorder (89%), and schizophrenia (82%). Psychosis not otherwise specified (13%) was more unstable, with limited baseline differences that would enable clinicians to predict who would convert to a primary psychotic vs affective psychotic disorder.

conclusionsOur real-world clinical sample shows that FEP diagnoses, with the exception of unspecified psychosis, are diagnostically stable, even without structured diagnostic interviews.

Indexed as

AdolescentAdultBipolar DisorderDiagnosis, DifferentialFemaleHumansMaleMental Health ServicesPsychotic DisordersRetrospective StudiesSchizophreniadiagnostic changediagnostic stabilityfirst episode psychosispsychosis NOSschizophrenia

Identifiers

PMID32043313
PMCPMC7774998

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.