Evidence map›Paper›PMID 32043256›Full record

ArticleObesity surgery2020

Long-term Impact of Mini-Gastric Bypass on Inflammatory Cytokines in Cohort of Morbidly Obese Patients: a Prospective Study.

Mohamed Abdalla Salman, Ahmed Abdallah, Hani Maurice Sabri Mikhail, Ahmed Abdelsalam, Ayman Helmy Ibrahim, Ahmed Abd El Aal Sultan, Mohamed El-Ghobary, Amro Abdelaziz Mohammed Ismail, Tarek Elsayed Abouelregal, Mahmoud Gouda Omar and 5 more

Abstract read
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In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Impact of Bariatric Surgery on Adipose Tissue Biology.Journal of clinical medicine · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Mohamed Abdalla SalmanGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ahmed AbdallahGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Hani Maurice Sabri MikhailGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ahmed AbdelsalamGeneral Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ayman Helmy IbrahimGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed Abd El Aal SultanGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID https://orcid.org/0000-0003-1097-2615
Mohamed El-GhobaryInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, Egypt.
Amro Abdelaziz Mohammed IsmailInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, Egypt.
Tarek Elsayed AbouelregalInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, Egypt.
Mahmoud Gouda OmarInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, Egypt.
Alhoussein Alsayed AbdelAalInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Hossam El-Din ShaabanNational Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Ghada M K GabAllahMedical Biochemistry Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt.
Mohamed TourkyAlawi Tunsi, Mecca, Saudi Arabia.
Ahmed Abdallah SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, 11311, Egypt. awea844@gmail.com.ORCID http://orcid.org/0000-0003-0026-0841
Cairo University · EGAl-Azhar University · EGMenoufia University · EGNational Water Research Center · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOne anastomosis gastric bypass (OAGB) is a promising bariatric procedure. We performed this study to evaluate the changes in a group of inflammatory cytokines 12 months after OAGB.

methodsA single-arm prospective study was conducted on obese patients who underwent OAGB. The serum levels of the following adipocytokines were monitored pre- and 12 months postoperatively: adiponectin, leptin, interleukin 6 (IL-6), interleukin 8 (IL-8) levels, tumor necrosis factor-alpha (TNF-α), serum amyloid A (SAA), high-sensitivity C-reactive protein (hs-CRP), and monocyte chemotactic protein 1 (MCP-1).

resultsA total of 62 patients were included with a mean age of 43.9 ± 6.8 years old. The serum adiponectin increased significantly from 7.64 ± 0.29 to 8.76 ± 0.42 μg/mL 12 months after the operation (p < 0.001). hs-CRP and IL-6 decreased significantly 12 months after the OAGB from 3323.35 ± 643.4 ng/mL and 3.72 ± 7.7 pg/mL to 1376.81 ± 609.4 ng/mL and 3.64 ± 6.9 pg/mL, respectively (p < 0.001). The MCP-1 showed significant increase in its level after OAGB as well (p = 0.014). In contrary, there were no significant changes in serum levels of IL-8 (p = 0.12) and TNF-α (p = 0.84) 12 months after the operation. The correlation analysis showed significant correlations between initial body mass index (BMI) with serum adiponectin, IL-8, and serum SAA.

conclusionOAGB can significantly impact the inflammatory cytokine profile in obese patients with possible subsequent protection from obesity-related comorbidities such as insulin resistance, cardiovascular diseases, and certain cancers.

Indexed as

Gastric BypassObesity, MorbidAdultCytokinesHumansMiddle AgedProspective StudiesWeight LossCytokinesBariatric surgeryInflammatory AdipokinesOne anastomosis gastric bypass

Identifiers

PMID32043256
OpenAlexW3006661629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.