ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Hypermetabolism of the spleen or bone marrow is an additional albeit indirect sign of infective endocarditis at FDG-PET.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02287792 (Effect of 18-FDG PET/CT Imaging on Clinical Decision Making During the Acute Phase of Infective Endocarditis), which is not on this map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of 18-FDG PET/CT Imaging on Clinical Decision Making During the Acute Phase of Infective Endocarditis: a Multicenter Prospective Impact Study
Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Innovations in Imaging:Current cardiology reports · 2024Review
- Splenic Embolism in Infective Endocarditis: A Systematic Review of the Literature with an Emphasis on Radiological and Histopathological Diagnoses.Tropical medicine and infectious disease · 2024Review
- SARS-CoV-2 Affects Thyroid and Adrenal Glands: AnBiomedicines · 2023Article
- Real world experience of therapeutic monitoring of medically treated prosthetic valve infective endocarditis byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Infective Endocarditis in Adults With Congenital Heart Disease: Never Stop Digging-The Role of Multimodality Imaging.JACC. Case reports · 2023Article
- Contemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis.Life (Basel, Switzerland) · 2023Review
- Computed tomography with positron emission tomography is more useful in local than systemic infectious process related to cardiac implanted electrotherapy device: a prospective controlled multicenter diagnostic intervention PET-Guidance Trial.The international journal of cardiovascular imaging · 2022Article
- [Journal of personalized medicine · 2022Article
- Lymphopenia in patients affected by SARS-CoV-2 infection is caused by margination of lymphocytes in large bowel: an [European journal of nuclear medicine and molecular imaging · 2022Article
- Nuclear Imaging in Infective Endocarditis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- FDG uptake in marrow and spleen: What does it mean? : Importance of clinical context in the interpretation of FDG uptake in marrow and spleen in infective endocarditis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Detection of Native and Prosthetic Valve Endocarditis: Incremental Attributes of Functional FDG PET/CT over Morphologic Imaging.Current cardiology reports · 2020Review
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed at determining the diagnostic implications of indirect signs of infection at FDG-PET-i.e., hypermetabolisms of the spleen and/or bone marrow (HSBM)-when documented in patients with known or suspected infective endocarditis (IE).
methodsHSBM were defined by higher mean standardized uptake values comparatively to that of the liver on FDG-PET images from patients with a high likelihood of IE and prospectively included in a multicenter study.
resultsAmong the 129 included patients, IE was ultimately deemed as definite in 88 cases. HSBM was a predictor of definite IE (P = 0.014; odds ratio (OR) 3.2), independently of the criterion of an abnormal cardiac FDG uptake (P = 0.0007; OR 9.68), and a definite IE was documented in 97% (29/30) of patients showing both HSBM and abnormal cardiac uptake, 78% (7/9) of patients with only abnormal cardiac uptake, 67% (42/63) of patients with only HSBM, and 37% (10/27) of patients with neither one.
conclusionIn this cohort with a high likelihood of IE, HSBM is an additional albeit indirect sign of IE, independently of the criterion of an abnormal cardiac uptake, and could reinforce the suspicion of IE in the absence of any other infectious, inflammatory, or malignant disease.
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