Evidence map›Paper›PMID 32043210›Full record

ArticleCell and tissue research2020

Attenuated regenerative properties in human periodontal ligament-derived stem cells of older donor ages with shorter telomere length and lower SSEA4 expression.

Tsz Kin Ng, Chong-Bo Chen, Ciyan Xu, Yanxuan Xu, Xiaowu Yao, Li Huang, Jia-Jian Liang, Herman S Cheung, Chi Pui Pang, Yuqiang Huang

Abstract read
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In one paragraph

Article in Cell and tissue research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
  5. Influence of age on stem cells depends on the sex of the bone marrow donor.Journal of cellular and molecular medicine · 2022
    Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Tsz Kin NgJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China. micntk@hotmail.com.ORCID http://orcid.org/0000-0001-7863-7229
Chong-Bo ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China.
Ciyan XuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China.
Yanxuan XuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China.
Xiaowu YaoDentistry Department, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Li HuangDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
Jia-Jian LiangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China.
Herman S CheungGeriatric Research, Education and Clinical Center, Miami Veterans Affairs Medical Center, Miami, FL, USA.
Chi Pui PangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China.
Yuqiang HuangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, North Dongxia Road, Shantou, 515041, Guangdong, China. hyq@jsiec.org.
Chinese University of Hong Kong · HKShantou University · CNUniversity of Miami · US

Funding

Internal grant from the Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong 18-001Natural Science Foundation of Guangdong Province 2016A030313063Special Fund for the Innovative Science and Technology Strategy of Guangdong Province 180918154960752
6 · The paper itself

Abstract

Periodontal ligament (PDL) stem cell properties are critical in the periodontal tissue regeneration for periodontitis. Previously, we have demonstrated that cigarette smoking attenuates PDL-derived stem cell (PDLSC) regenerative properties. Here, we report the findings on the regenerative properties of human PDLSCs with different donor ages and the underlying mechanisms. Human PDLSCs from 18 independent donors were divided into different age groups (≤ 20, 20-40, and > 40 years old). The proliferation of PDLSCs with donor age of ≤ 20 years old was significantly higher than that of the 20-40- and > 40-years-old groups, whereas the migration of PDLSCs with donor age of ≤ 20 and 20-40 years old was significantly higher than that of the > 40-years-old group. Moreover, the mesodermal lineage differentiation capabilities of PDLSCs were also higher in the donor age group of ≤ 20 years old than the donor age of > 40 years old. In addition, shorter telomere length and lower expression of SSEA4 were found in PDLSCs with donor age of > 40 years old, compared with those with donor age of ≤ 20-years-old group. Besides, PDLSCs with donor age of 20-40 and > 40 years old had higher IL6 and CXCL8 gene expressions. In summary, results from this study revealed the attenuated proliferation, migration, and mesodermal lineage differentiation properties in human PDLSCs with older donor ages. Donor age of PDLSCs should be considered as the selection criteria for the periodontal tissue regeneration treatment.

Indexed as

Age FactorsAdultCell ProliferationCells, CulturedChronic PeriodontitisFemaleGuided Tissue Regeneration, PeriodontalHumansInterleukin-6Interleukin-8MaleOsteogenesisPeriodontal LigamentStage-Specific Embryonic AntigensStem CellsTelomereCXCL8 protein, humanIL6 protein, humanInterleukin-6Interleukin-8stage-specific embryonic antigen-4Stage-Specific Embryonic AntigensAge effectHuman periodontal ligament–derived stem cellsRegenerative propertiesSSEA4Telomere

Identifiers

PMID32043210
OpenAlexW3004426682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.