ArticleCerebral cortex (New York, N.Y. : 1991)2020
Local Perturbations of Cortical Excitability Propagate Differentially Through Large-Scale Functional Networks.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Cortical Hyperexcitability Shapes Large-Scale Brain Dynamics and Behavioral Outcome in Angelman Syndrome.Biological psychiatry global open science · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structure-function coupling in the first month of life: Associations with age and attention.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice.Neurophotonics · 2025Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice.GeroScience · 2024Article
- Network-specific metabolic and haemodynamic effects elicited by non-invasive brain stimulation.Nature. Mental health · 2023Article
- Simultaneous transcranial electrical and magnetic stimulation boost gamma oscillations in the dorsolateral prefrontal cortex.Scientific reports · 2022Article
- Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity.NeuroImage · 2022Article
- A Hybrid Titanium-Softmaterial, High-Strength, Transparent Cranial Window for Transcranial Injection and Neuroimaging.Biosensors · 2022Article
- The diversity and specificity of functional connectivity across spatial and temporal scales.NeuroImage · 2021Review
- Brain activity is not only for thinking.Current opinion in behavioral sciences · 2021Article
- Through the looking glass: A review of cranial window technology for optical access to the brain.Journal of neuroscience methods · 2021Review
- Opposed hemodynamic responses following increased excitation and parvalbumin-based inhibition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Cingulo-opercular control network and disused motor circuits joined in standby mode.Proceedings of the National Academy of Sciences of the United States of America · 2021Observational
- Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Electrophysiological recordings have established that GABAergic interneurons regulate excitability, plasticity, and computational function within local neural circuits. Importantly, GABAergic inhibition is focally disrupted around sites of brain injury. However, it remains unclear whether focal imbalances in inhibition/excitation lead to widespread changes in brain activity. Here, we test the hypothesis that focal perturbations in excitability disrupt large-scale brain network dynamics. We used viral chemogenetics in mice to reversibly manipulate parvalbumin interneuron (PV-IN) activity levels in whisker barrel somatosensory cortex. We then assessed how this imbalance affects cortical network activity in awake mice using wide-field optical neuroimaging of pyramidal neuron GCaMP dynamics as well as local field potential recordings. We report 1) that local changes in excitability can cause remote, network-wide effects, 2) that these effects propagate differentially through intra- and interhemispheric connections, and 3) that chemogenetic constructs can induce plasticity in cortical excitability and functional connectivity. These findings may help to explain how focal activity changes following injury lead to widespread network dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.