ArticleCerebral cortex (New York, N.Y. : 1991)2020
Neural Dedifferentiation across the Lifespan in the Motor and Somatosensory Systems.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural correlates of harm avoidance: a multimodal meta-analysis of brain structural and resting-state functional neuroimaging studies.Translational psychiatry · 2024Pooled it
- Neural correlates of dual-task walking in people with central neurological disorders: a systematic review.Journal of neurology · 2022Pooled it
- Is Dual-Task Training Clinically Beneficial to Improve Balance and Executive Function in Community-Dwelling Older Adults with a History of Falls?International journal of environmental research and public health · 2022Trial
- Prefrontal Cortical Asymmetry and Motor Slowing in Older Women: EEG Evidence That Fear of Falling Modulates Emotional Valence and Reaction Time.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Sub-Regional Motor-Somatosensory Connectivity and Lifespan Plasticity in Functional Networks.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Large reaching datasets quantify the impact of age, sex/gender, and experience on motor control.Communications psychology · 2026Article
- The ageing brain: Cortical overactivation - How does it evolve?The Journal of physiology · 2026Review
- Comparing arm to whole-body motor control disambiguates age-related deterioration from compensation.Frontiers in aging · 2026Article
- Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques.Nature aging · 2025Article
- Repetition Hampers Flexible Object Manipulation Under Visual Uncertainty.The European journal of neuroscience · 2025Article
- Investigating age-related decline in sensorimotor control using robotic tasks.Frontiers in aging neuroscience · 2025Article
- Neural Encoding of Direction and Distance across Reference Frames in Visually Guided Reaching.eNeuro · 2024Article
- Decline in Sensory Integration in Old Age and Its Related Functional Brain Connectivity Correlates Observed during a Virtual Reality Task.Brain sciences · 2024Article
- Asynchronous behavioral and neurophysiological changes in word production in the adult lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Changes in working memory brain activity and task-based connectivity after long-duration spaceflight.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age-related declines in neural distinctiveness correlate across brain areas and result from both decreased reliability and increased confusability.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- tDCS over the primary motor cortex contralateral to the trained hand enhances cross-limb transfer in older adults.Frontiers in aging neuroscience · 2022Article
- Does Hemispheric Asymmetry Reduction in Older Adults in Motor Cortex Reflect Compensation?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The organizational principles of de-differentiated topographic maps in somatosensory cortex.eLife · 2021Article
- Occupation-related effects on motor cortex thickness among older, cognitive healthy individuals.Brain structure & function · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Age-related declines in sensorimotor performance have been linked to dedifferentiation of neural representations (i.e., more widespread activity during task performance in older versus younger adults). However, it remains unclear whether changes in neural representations across the adult lifespan are related between the motor and somatosensory systems, and whether alterations in these representations are associated with age declines in motor and somatosensory performance. To investigate these issues, we collected functional magnetic resonance imaging and behavioral data while participants aged 19-76 years performed a visuomotor tapping task or received vibrotactile stimulation. Despite one finding indicative of compensatory mechanisms with older age, we generally observed that 1) older age was associated with greater activity and stronger positive connectivity within sensorimotor and LOC regions during both visuomotor and vibrotactile tasks; 2) increased activation and stronger positive connectivity were associated with worse performance; and 3) age differences in connectivity in the motor system correlated with those in the somatosensory system. Notwithstanding the difficulty of disentangling the relationships between age, brain, and behavioral measures, these results provide novel evidence for neural dedifferentiation across the adult lifespan in both motor and somatosensory systems and suggest that dedifferentiation in these two systems is related.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.