Evidence map›Paper›PMID 32043043›Full record

ReviewNetwork neuroscience (Cambridge, Mass.)2020

Questions and controversies in the study of time-varying functional connectivity in resting fMRI.

Daniel J Lurie, Daniel Kessler, Danielle S Bassett, Richard F Betzel, Michael Breakspear, Shella Kheilholz, Aaron Kucyi, Raphaël Liégeois, Martin A Lindquist, Anthony Randal McIntosh and 13 more

Abstract readReview
In one paragraph

Review in Network neuroscience (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 377 papers.

0numbers the graph read from it
0cells of the map it votes in
377citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

377 citing papers in PubMed.

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  4. Sharp and smooth state transitions during resting state brain dynamics.bioRxiv : the preprint server for biology · 2026
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  19. Functional brain organization is stable within individuals across years.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

317 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Daniel J LurieDepartment of Psychology, University of California, Berkeley, Berkeley, CA, USA.ORCID https://orcid.org/0000-0001-8012-6399
Daniel KesslerDepartments of Statistics and Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0003-2052-025X
Danielle S BassettDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-6183-4493
Richard F BetzelDepartment of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0001-9200-1681
Michael BreakspearUniversity of Newcastle, Callaghan, NSW, 2308, Australia.ORCID https://orcid.org/0000-0003-4943-3969
Shella KheilholzDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.ORCID https://orcid.org/0000-0001-5737-1660
Aaron KucyiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford CA, USA.ORCID https://orcid.org/0000-0001-6707-0028
Raphaël LiégeoisInstitute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-3985-3898
Martin A LindquistDepartment of Biostatistics, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-2289-0828
Anthony Randal McIntoshRotman Research Institute - Baycrest Centre, Toronto, Canada.ORCID https://orcid.org/0000-0002-1784-5662
Russell A PoldrackDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0001-6755-0259
James M ShineBrain and Mind Centre, University of Sydney, NSW, Australia.ORCID https://orcid.org/0000-0003-1762-5499
William Hedley ThompsonDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0002-0533-6035
Natalia Z BielczykStichting Solaris Onderzoek en Ontwikkeling, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0003-1604-9143
Linda DouwDepartment of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-7058-4062
Dominik KraftDepartment of Psychology, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-4964-2237
Robyn L MillerThe Mind Research Network, Albuquerque, NM, USA.ORCID https://orcid.org/0000-0002-4679-7567
Muthuraman MuthuramanBiomedical Statistics and Multimodal Signal Processing Unit, Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience, Johannes-Gutenberg-University Hospital, Mainz, Germany.ORCID https://orcid.org/0000-0001-6158-2663
Lorenzo PasquiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-7899-7061
Adeel RaziMonash Institute of Cognitive and Clinical Neurosciences and Monash Biomedical Imaging, Monash University, Clayton, Australia.ORCID https://orcid.org/0000-0002-0779-9439
Diego VidaurreWellcome Trust Centre for Integrative Neuroimaging, Oxford Centre for Human Brain Activity, University of Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-9650-2229
Hua XieDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0000-0003-3462-0147
Vince D CalhounThe Mind Research Network, Albuquerque, NM, USA.ORCID https://orcid.org/0000-0001-9058-0747

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Pilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Linguistic and NonLinguistic Functions of Frontal CortexR01DC009209 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI THOMPSONSCHILL, SHARON L · 2008 to 2018
$5.2M
Individualized spatial topology in functional neuroimagingR01EB026549 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Abhirup Datta, Martin Lindquist · 2018 to 2026
$4.5M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Flexible multivariate models for linking multi-scale connectome and genome data in Alzheimer's disease and related disordersRF1AG063153 · NIA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2020
$3.5M
Contribution of Ultra Low Frequency LFPs to Functional MRIR01NS078095 · NINDS · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D · 2012 to 2022
$3.4M
Data-driven solutions for temporal, spatial, and spatiotemporal dynamic functional connectivityR01MH123610 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2021 to 2025
$3.1M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Longitudinal Causal Inferencer for fMRIR01EB016061 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI LINDQUIST, MARTIN · 2013 to 2020
$2.3M
NIA NIH HHS RF1 AG063153NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB016061NIBIB NIH HHS R01 EB020407NIBIB NIH HHS R01 EB026549NICHD NIH HHS R01 HD086888NIDCD NIH HHS R01 DC009209NIGMS NIH HHS P20 GM103472NIGMS NIH HHS P30 GM122734NIMH NIH HHS R01 MH107235NIMH NIH HHS R01 MH111416NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH118695NIMH NIH HHS R01 MH123610NIMH NIH HHS R21 MH106799NINDS NIH HHS F31 NS108665NINDS NIH HHS R01 NS078095NINDS NIH HHS R01 NS099348
6 · The paper itself

Abstract

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge of the spatiotemporal organization of these interactions is critical for establishing a solid understanding of the brain's functional architecture and the relationship between neural dynamics and cognition in health and disease. The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods that estimate time-resolved fluctuations in functional connectivity (often referred to as "dynamic" or time-varying functional connectivity; TVFC). At the same time, debates have emerged regarding the application of TVFC analyses to resting fMRI data, and about the statistical validity, physiological origins, and cognitive and behavioral relevance of resting TVFC. These and other unresolved issues complicate interpretation of resting TVFC findings and limit the insights that can be gained from this promising new research area. This article brings together scientists with a variety of perspectives on resting TVFC to review the current literature in light of these issues. We introduce core concepts, define key terms, summarize controversies and open questions, and present a forward-looking perspective on how resting TVFC analyses can be rigorously and productively applied to investigate a wide range of questions in cognitive and systems neuroscience.

Indexed as

Brain dynamicsBrain networksfMRIFunctional connectivityRestReview

Identifiers

PMID32043043
PMCPMC7006871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.