ArticleKidney international reports2020
Secondary IgA Nephropathy Shares the Same Immune Features With Primary IgA Nephropathy.
Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Examining the association between serum galactose-deficient IgA1 and primary IgA nephropathy: a systematic review and meta-analysis.Journal of nephrology · 2024Pooled it
- Article
- The role of mucosal immune dysregulation in the pathogenesis of immunoglobulin A nephropathy.Frontiers in immunology · 2026Review
- Gut microbiome dysregulation is associated with segmental glomerulosclerosis in IgA nephropathy: insights from Oxford classification-based microbiome profiling.Frontiers in cellular and infection microbiology · 2026Article
- Significance of KM55 immunohistochemical staining in the diagnosis and prognosis of IgA nephropathy.Journal of pathology and translational medicine · 2026Article
- Glomerular galactose-deficient IgA1 and apoptosis inhibitor of macrophage staining in secondary IgA nephropathy associated with alcoholic cirrhosis.Journal of nephrology · 2025Article
- Acute kidney injury after treatment with arsenic trioxide.Clinical nephrology. Case studies · 2025Article
- Two Concomitant Rare Extraglandular Manifestations of Primary Sjögren's Syndrome: IgA Nephropathy and Autoimmune Hepatitis.Mediterranean journal of rheumatology · 2024Article
- Clinical Presentation, Pathological Spectrum, and Outcomes of Alcoholic Cirrhosis-Related Immunoglobulin A Nephropathy.Kidney international reports · 2024Article
- Effect of Telitacicept on Circulating Gd-IgA1 and IgA-Containing Immune Complexes in IgA Nephropathy.Kidney international reports · 2024Article
- Role of telitacicept in the treatment of IgA nephropathy.European journal of medical research · 2023Review
- The significance of galactose-deficient immunoglobulin A1 staining in kidney diseases with IgA deposition.International urology and nephrology · 2023Article
- Galactose-deficient IgA1 Is Involved in IgA Deposition in Renal Grafts Biopsied One Hour after Kidney Transplantation.Internal medicine (Tokyo, Japan) · 2023Article
- A child with abdominal pain, arthralgia, palpable skin rash, hepatosplenomegaly, and pancytopenia: Answers.Pediatric nephrology (Berlin, Germany) · 2023Article
- Secondary IgA Nephropathy and IgA-Associated Nephropathy: A Systematic Review of Case Reports.Journal of clinical medicine · 2023Review
- [Changes of gut microflora in newly diagnosed IgA nephropathy patients and its correlation with clinical risk factors].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Causal effects between gut microbiota and IgA nephropathy: a bidirectional Mendelian randomization study.Frontiers in cellular and infection microbiology · 2023Article
- Crohn's disease may promote inflammation in IgA nephropathy: a case-control study of patients undergoing kidney biopsy.Virchows Archiv : an international journal of pathology · 2022Article
- Oxidative stress and macrophage infiltration in IgA nephropathy.Journal of nephrology · 2022Article
- KM55 in the Evaluation of IgA-Containing Glomerular Diseases.Glomerular diseases · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGalactose-deficient IgA1 (Gd-IgA1) and related IgA/IgG immune complexes have been identified as the key drivers in the pathogenesis of IgA nephropathy (IgAN). However, their roles in the development of secondary IgAN are still unknown.
methodsIn this study, we measured the plasma Gd-IgA1 level, IgA/IgG complex, and Gd-IgA1 glomerular deposits in 100 patients with various kinds of secondary IgAN. Plasma Gd-IgA1 was measured using a lectin-based enzyme-linked immunosorbent assay, and Gd-IgA1 in glomerular deposits was examined by double immunofluorescent staining using its specific monoclonal antibody KM55.
resultsPatients with secondary IgAN presented with higher plasma Gd-IgA1 levels compared to healthy controls (median, 354.61 U/ml; interquartile range [IQR], 323.93, 395.57 U/ml vs. median, 303.17 U/ml; IQR, 282.24, 337.92 U/ml,
conclusionOur study strongly suggests that secondary IgAN shares a similar galactose-deficient IgA1-oriented pathogenesis with primary IgAN.
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