Evidence map›Paper›PMID 32043018›Full record

ArticleJACC. Basic to translational science2020

Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements.

Emanuela S Fioretta, Valentina Lintas, Anna Mallone, Sarah E Motta, Lisa von Boehmer, Petra E Dijkman, Nikola Cesarovic, Etem Caliskan, Héctor Rodriguez Cetina Biefer, Miriam Lipiski and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Materials Advances in Devices for Heart Disease Interventions.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. The Application of Porous Scaffolds for Cardiovascular Tissues.Bioengineering (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Bioresorbable Polymeric Scaffold in Cardiovascular Applications.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Emanuela S FiorettaInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Valentina LintasInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Anna MalloneInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Sarah E MottaInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Lisa von BoehmerInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Petra E DijkmanInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Nikola CesarovicDivision of Surgical Research, University of Zürich, Zürich, Switzerland.
Etem CaliskanDepartment of Cardiovascular Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.
Héctor Rodriguez Cetina BieferDepartment of Cardiovascular Surgery, University Hospital Zürich, Zürich, Switzerland.
Miriam LipiskiDivision of Surgical Research, University of Zürich, Zürich, Switzerland.
Mareike SauerDivision of Surgical Research, University of Zürich, Zürich, Switzerland.
Matilde PuttiDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Henk M JanssenSyMO-Chem B.V., Eindhoven, the Netherlands.
Serge H SöntjensSyMO-Chem B.V., Eindhoven, the Netherlands.
Anthal I P M SmitsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Carlijn V C BoutenDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Maximilian Y EmmertInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
Simon P HoerstrupInstitute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell-scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.

Indexed as

B-GLAP, bone gamma-carboxyglutamateBMMNC, bone marrow mononuclear cellsBVG, bioresorbable vascular graftcardiovascular regenerative medicineCXCL12, stromal cell-derived factor-1α (SDF1α)ECM, extracellular matrixendogenous tissue regenerationIL, interleukinin situ tissue engineeringMCP, monocyte chemoattractant proteinMMP, matrix metalloproteinasePC-BU, polycarbonate bisureaSMA, smooth muscle actinsupramolecular polymerTEE, transesophageal echocardiographyTEHV, tissue-engineered heart valveTGF, transforming growth factortissue-engineered heart valveTVR, transcatheter valve replacement

Identifiers

PMID32043018
PMCPMC7000873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.