ArticleScience advances2020
Direct observation of glucose fingerprint using in vivo Raman spectroscopy.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 220 citations in OpenAlex.
- A Multifrequency Millimeter-Wave CMOS Sensor for Non-Invasive Continuous Glucose Monitoring Using UMC 0.18 μm Technology.Biosensors · 2026Article
- Non-Invasive Technologies in Wearable Glucose Monitoring: A Structured Overview for the Future.Biosensors · 2026Review
- Workshop on Noninvasive Glucose Monitoring 2025.Journal of diabetes science and technology · 2026Article
- Longitudinal Monitoring of Metabolic Gradients in Microreactor Culture Platforms by Raman Spectroscopy.Biosensors · 2026Article
- Mitochondria-Targeted Au@Carbon Dot Nanoprobes for SERS Analysis of Drug-Induced Mitophagy.Chemical & biomedical imaging · 2026Article
- Real-time multimodal phenotyping reveals distinct tumour cell dynamics and immune escape mechanisms in T cell therapies.Nature biomedical engineering · 2026Article
- Article
- Band-Pass Raman Spectroscopy Unlocks Compact Point-of-Care Noninvasive Continuous Glucose Monitoring.Analytical chemistry · 2025Article
- Borohydride Synthesis of Silver Nanoparticles for SERS Platforms: Indirect Glucose Detection and Analysis Using Gradient Boosting.Sensors (Basel, Switzerland) · 2025Article
- A low-power approach to optical glucose sensing via polarisation switching.Scientific reports · 2025Article
- Calibration and performance of a Raman-based device for non-invasive glucose monitoring in type 2 diabetes.Scientific reports · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina.Biomedical optics express · 2025Article
- A Compact Wideband Vivaldi Antenna for Non-Invasive Glucose Monitoring.Micromachines · 2024Article
- High-Throughput Raman Spectroscopy by Horizontally Shifted Collection Fibers.Analytical chemistry · 2024Article
- Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography.Communications biology · 2024Article
- Swept-source Raman spectroscopy of chemical and biological materials.Journal of biomedical optics · 2024Article
- Optics miniaturization strategy for demanding Raman spectroscopy applications.Nature communications · 2024Article
- Engineering vascularized skin-mimetic phantom for non-invasive Raman spectroscopy.Sensors and actuators. B, Chemical · 2024Article
- Machine Learning Method and Hyperspectral Imaging for Precise Determination of Glucose and Silicon Levels.Sensors (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Noninvasive blood glucose monitoring has been a long-standing dream in diabetes management. The use of Raman spectroscopy, with its molecular specificity, has been investigated in this regard over the past decade. Previous studies reported on glucose sensing based on indirect evidence such as statistical correlation to the reference glucose concentration. However, these claims fail to demonstrate glucose Raman peaks, which has raised questions regarding the effectiveness of Raman spectroscopy for glucose sensing. Here, we demonstrate the first direct observation of glucose Raman peaks from in vivo skin. The signal intensities varied proportional to the reference glucose concentrations in three live swine glucose clamping experiments. Tracking spectral intensity based on linearity enabled accurate prospective prediction in within-subject and intersubject models. Our direct demonstration of glucose signal may quiet the long debate about whether glucose Raman spectra can be measured in vivo in transcutaneous glucose sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.