Evidence map›Paper›PMID 32042895›Full record

ArticleScience advances2020

Environmental and genetic determinants of plasmid mobility in pathogenic

Jonathan H Bethke, Adam Davidovich, Li Cheng, Allison J Lopatkin, Wenchen Song, Joshua T Thaden, Vance G Fowler, Minfeng Xiao, Lingchong You

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  7. Fluid flow generates bacterial conjugation hot spots by increasing the rate of shear-driven cell-cell encounters.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  20. Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan H BethkeDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-9900-2369
Adam DavidovichDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-2543-1873
Li ChengBGI-Shenzhen, Shenzhen 518083, China.
Allison J LopatkinDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-0018-9205
Wenchen SongBGI-Shenzhen, Shenzhen 518083, China.
Joshua T ThadenDepartment of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
Vance G FowlerDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-8048-0897
Minfeng XiaoBGI-Shenzhen, Shenzhen 518083, China.ORCID 0000-0002-0507-7352
Lingchong YouDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-3725-4007

Funding

Post-antibiotic effect and design of optimal antibiotic dosing protocolsR01GM098642 · NIGMS · DUKE UNIVERSITY · PI YOU, LINGCHONG · 2011 to 2025
$3.6M
Tradeoffs between fitness costs and transfer rates in horizontal gene transferR01AI125604 · NIAID · DUKE UNIVERSITY · PI LINGCHONG YOU · 2017 to 2026
$3.3M
NIAID NIH HHS R01 AI125604NIGMS NIH HHS R01 GM098642
6 · The paper itself

Abstract

Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance, virulence, and other traits among bacterial populations. The environmental and genetic forces that drive plasmid transfer are poorly understood, however, due to the lack of definitive quantification coupled with genomic analysis. Here, we integrate conjugative phenotype with plasmid genotype to provide quantitative analysis of HGT in clinical

Indexed as

Conjugation, GeneticGene Transfer, HorizontalGenome, BacterialAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliPlasmidsWhole Genome SequencingAnti-Bacterial Agents

Identifiers

PMID32042895
PMCPMC6981087

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.