Evidence map›Paper›PMID 32042867›Full record

ArticleGenes & diseases2019

Effect of the electro-acupuncture on senile plaques and its formation in APP

Qinghua Yang, Shujuan Zhu, Jin Xu, Chenglin Tang, Kaihui Wu, Yanjun Wu, Yiying Wang, Huajun Sheng

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Moxibustion improves hypothalamusFrontiers in aging neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qinghua YangInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Shujuan ZhuInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Jin XuInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Chenglin TangCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
Kaihui WuInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Yanjun WuInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Yiying WangInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Huajun ShengInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease and its incidence will increase with age and is aggravating. The senile plaques (SPs) are one of three main pathological features in AD patients, which are formed by amyloid β-protein (Aβ) over-accumulation. β-amyloid precursor protein (APP), β-site APP cleavage (BACE1), and insulin degrading enzyme (IDE) proteins participate in the process of Aβ production and degradation. At present, the pathogenesis of AD is not yet clear and the current treatment methods can only relief the related symptoms of AD. The electro-acupuncture (EA) is a traditional Chinese medicine treatment combined the acupuncture and electrical stimulation and the treatment effect can also be controlled by transform the electrical frequency. Thus, in this experiment, we carried out behavioral test, immunohistochemistry (IHC), and Western Blot (WB) after different period treatments to the model mice by electro-acupuncturing "Baihui" and "Shenshu" acupoints in APP

Indexed as

Ach, aetylcholineAchE, cholinesteraseAD, Alzheimer's diseaseAlzheimer's diseaseamyloid precursor protein, BACE1Amyloid β-proteinAPP, β－Aβ, amyloid β-proteinChAT, aetylcholine tansferaseEA, electro-acupunctureElectro-acupunctureIDE, insulin degrading enzymeIHC, immunohistochemistrySenile plaquesSOD, superoxide dismutaseSPs, senile plaquesTransgenic miceβ－, site APP cleavage

Identifiers

PMID32042867
PMCPMC6997572
OpenAlexW2808389918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.