ArticleNeurophotonics2020
Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis.
Article in Neurophotonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Structure-Aware OCTA Segmentation for OCTA-Derived Quantitative Analysis of Cerebral Microvascular Perfusion in Ischemic Stroke.Tomography (Ann Arbor, Mich.) · 2026Article
- Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mapping of blood flow and slow speckle tissue dynamics using laser speckle contrast imaging.Biomedical optics express · 2025Article
- Machine learning-based method to detect capillary stalling using optical coherence tomography.Biomedical optics express · 2025Article
- Optical coherence tomography enables longitudinal evaluation of cell graft-directed remodeling in stroke lesions.Experimental neurology · 2025Article
- Laser speckle imaging of the hippocampus.Biomedical optics express · 2024Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
- Choosing a polarisation configuration for dynamic light scattering and laser speckle contrast imaging.Biomedical optics express · 2024Article
- Article
- Optimizing the precision of laser speckle contrast imaging.Scientific reports · 2023Article
- Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Measurements of slow tissue dynamics with short-separation speckle contrast optical spectroscopy.Biomedical optics express · 2023Article
- High throughput detection of capillary stalling events with Bessel beam two-photon microscopy.Neurophotonics · 2023Article
- Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke.Journal of the American Heart Association · 2023Article
- Measuring capillary flow dynamics using interlaced two-photon volumetric scanning.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Photothrombotic Middle Cerebral Artery Occlusion in Mice: A Novel Model of Ischemic Stroke.eNeuro · 2023Article
- Article
- In vivo tissue optical clearing assisted through-skull targeted photothrombotic ischemic stroke model in mice.Journal of biomedical optics · 2022Article
- Multi-scale laser speckle contrast imaging of microcirculatory vasoreactivity.Biomedical optics express · 2022Article
- Depth-targeted intracortical microstroke by two-photon photothrombosis in rodent brain.Neurophotonics · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Animal models of stroke are used extensively to study the mechanisms involved in the acute and chronic phases of recovery following stroke. A translatable animal model that closely mimics the mechanisms of a human stroke is essential in understanding recovery processes as well as developing therapies that improve functional outcomes. We describe a photothrombosis stroke model that is capable of targeting a single distal pial branch of the middle cerebral artery with minimal damage to the surrounding parenchyma in awake head-fixed mice. Mice are implanted with chronic cranial windows above one hemisphere of the brain that allow optical access to study recovery mechanisms for over a month following occlusion. Additionally, we study the effect of laser spot size used for occlusion and demonstrate that a spot size with small axial and lateral resolution has the advantage of minimizing unwanted photodamage while still monitoring macroscopic changes to cerebral blood flow during photothrombosis. We show that temporally guiding illumination using real-time feedback of blood flow dynamics also minimized unwanted photodamage to the vascular network. Finally, through quantifiable behavior deficits and chronic imaging we show that this model can be used to study recovery mechanisms or the effects of therapeutics longitudinally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.