ReviewAnnals of translational medicine2019
Suggestions for designing studies investigating diagnostic accuracy of biomarkers.
Review in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Assessment of diagnostic efficacy: High fluorescent cells combined with CEA, NSE, and Cyfra21-1 in Malignant Pleural Effusion Identification.Malawi medical journal : the journal of Medical Association of Malawi · 2025Article
- Diagnostic accuracy of pleural fluid carbohydrate antigen 72-4 for malignant pleural effusion: a systematic review and meta-analysis.Translational cancer research · 2025Article
- The combined use of serum Raman spectroscopy and D dimer testing for the early diagnosis of acute aortic dissection.Heliyon · 2024Article
- Significance of Oxidative Stress in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration.Biochemical genetics · 2024Article
- Article
- Age affects the diagnostic accuracy of the cancer ratio for malignant pleural effusion.BMC pulmonary medicine · 2023Article
- Serum diagnostic markers for malignant pleural mesothelioma: a narrative review.Translational cancer research · 2022Review
- Noncoding RNome as Enabling Biomarkers for Precision Health.International journal of molecular sciences · 2022Review
- Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration.Journal of immunology research · 2022Article
- Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis.Translational cancer research · 2021Article
- Pleural biomarkers in diagnostics of malignant pleural effusion: a narrative review.Translational lung cancer research · 2021Review
- Diagnostic value of microRNAs for malignant pleural mesothelioma: A mini-review.Thoracic cancer · 2021Review
- Value of human epididymis secretory protein 4 in differentiating malignant from benign pleural effusion: an analysis of two cohorts.Therapeutic advances in respiratory diseaseArticle
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of diagnostic test accuracy (DTA) studies concerning biomarkers have gradually increased during the past years. However, study designs remain imperfect, and the statistical methods used are not meaningful in some published studies. Here, we introduce recommendations for designing DTA studies, including consecutive enrollment of participants with uniform inclusion and exclusion criteria, blinded testing and interpretation, prespecified thresholds, and the use of one reference standard for all subjects. In addition, we also describe more relevant statistical methods in DTA studies, including decision curve analysis (DCA), nomograms, diagnostic model and scale, net reclassification index (NRI), and the integrated discriminatory index (IDI). This review may help clinicians to better design DTA studies that investigating biomarkers.
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