Evidence map›Paper›PMID 32042785›Full record

ArticleAnnals of translational medicine2019

The unique prognostic characteristics of tumor deposits in colorectal cancer patients.

Fangqi Liu, Jiang Zhao, Cong Li, Yuchen Wu, Wang Song, Tianan Guo, Shiqing Chen, Sanjun Cai, Dan Huang, Ye Xu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fangqi LiuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Jiang ZhaoDepartment of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai 200031, China.
Cong LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Yuchen WuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Wang SongDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Tianan GuoDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Shiqing ChenThe Medical Department, 3D Medicines Inc., Shanghai 201114, China.
Sanjun CaiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Dan HuangDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Ye XuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Fudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CNShanghai Xuhui Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth AJCC 7th and 8th TNM systems have included tumor deposits (TDs) in nodal staging when lymph nodes metastases (LNMs) are negative in colorectal cancer (CRC). However, the prognostic role of TDs has not been determined in the presence of positive LNMs.

methodsTwo independent large-scale cohorts of CRC patients from the Surveillance Epidemiology and End Results (SEER) database (n=69,178) [2010-2013] and Fudan University Shanghai Cancer Center (FUSCC) (n=3,137) [2010-2014] were retrospectively analyzed. Kaplan-Meier method was used to estimate survival curves and univariate and multivariate analyses were performed by Cox proportional hazard model.

resultsTDs were observed in 12.3% (n=8,480) and 14.8% (n=463) of patients in the SEER and FUSCC cohorts, respectively. Multivariate analysis suggested TDs were an independent adverse prognostic factors for overall survival (OS) (P<0.001). Remarkably, both cohorts showed the presence of TDs was significantly associated with OS, but not was the number of TDs (P=0.982 and P=0.252 for the SEER and FUSCC cohorts, respectively). In the presence of LNMs, positive TDs were associated with a shorter OS [hazard ratio (HR): 2.69, 95.0% confidence interval (CI): 2.597-2.778; P<0.001]. Further analysis combining TDs with LNMs demonstrated that the prognosis of patients with N1TD (N1 with positive TDs) was same as the N2 patients, and N2TD (N2 with positive TDs) patients had much worse prognosis than N2 (P<0.001).

conclusionsOur results have shown the unique features of TDs in patients with CRC, different from LNMs. In the presence of LNMs, TDs should also be considered in TMN system.

Indexed as

colorectal cancer (CRC)lymph nodes metastasis (LNM)prognosisTNM systemTumor deposits (TDs)

Identifiers

PMID32042785
PMCPMC6990005
OpenAlexW2995320767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.