ArticleAnnals of translational medicine2019
Traumatic macular hole study: a multicenter comparative study between immediate vitrectomy and six-month observation for spontaneous closure.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Vitrectomy vs. Spontaneous Closure for Traumatic Macular Hole: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Injury Patterns in Soccer-Induced Maxillofacial Fractures and Ocular Trauma: A Narrative Review.Sports medicine - open · 2026Review
- Repair of a Chronic, Traumatic Pediatric Macular Hole Using an Internal Limiting Membrane Flap and Direct Silicone Oil "Drop" Stabilization: A Case Report.Reports (MDPI) · 2026Article
- Visual and anatomical outcomes of full-thickness macular hole surgery and associated factors in selected hospitals in Tanzania.PloS one · 2026Article
- Characteristics and surgical outcomes of pediatric traumatic macular holes.BMC ophthalmology · 2025Article
- Pediatric macular hole repair with amniotic membrane graft in a patient with leukemia.American journal of ophthalmology case reports · 2025Article
- Management of traumatic macular hole and retinal detachment using amniotic membrane transplantation: A case report.American journal of ophthalmology case reports · 2025Article
- Comparative analysis of pre-operative findings and post-operative outcomes in primary and secondary macular holes at a tertiary eye hospital in South India.International journal of retina and vitreous · 2024Article
- Macular holes following vitrectomy for rhegmatogenous retinal detachment: epiretinal proliferation and spontaneous closure of macular holes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Vitreoretinal Society of India practice pattern survey 2020: Surgical retina.Indian journal of ophthalmology · 2021Article
- Traumatic macular holes: to operate, or not to operate, that is the question.Annals of translational medicine · 2020Article
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10 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClosure of traumatic macular hole (TMH) can be achieved spontaneously or by surgical intervention. Thus far, there exist no prospective comparative studies that have analyzed the difference between the two modalities. This study aimed to compare the anatomical and visual recovery of eyes with TMH following either an immediate vitrectomy or six-month observation.
methodsThis was a multicenter prospective comparative study. Eight centers participated in the study. Patient data from 40 eyes with a recent history of blunt ocular trauma and newly formed full-thickness TMH were recruited in this study. The participating patients selected between an early vitrectomy or a six-month observation after a doctor explained the potential benefits and risks of both strategies in an unbiased manner. Twenty-five patients underwent an immediate vitrectomy, and 15 patients received six-month observation. Patients were assessed by spectral-domain optical coherence tomography (SD-OCT) and best-corrected visual acuity (BCVA).
resultsClosure rates were 66.7% for the observational group, and 100% for the surgical group (P=0.002). There were no vision-threatening ocular complications in both groups. For the observational group, the mean closure time was 2.5±1.6 months, and 80% of the hole closure occurred within 3 months; cystic edema on the edge of the hole at baseline was significantly more frequent in the non-closed subgroup than in the closed subgroup (P=0.03). There were no significant differences in the foveal microstructure and in the final visual outcome between the spontaneously closed cases and the surgically closed cases.
conclusionsTMH had a moderately high incidence of spontaneous closure, but an immediate vitrectomy achieved an even higher closure rate. Vitrectomy was effective and safe to treat TMH, while a 3-month observation for spontaneous closure may be an alternative modality for TMH management. Cystic edema on the edge of the hole may be an unfavorable factor for the spontaneous closure of TMH.
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