Evidence map›Paper›PMID 32042612›Full record

ArticlePublic health action2019

Scaling up HIV viral load monitoring in Manicaland, Zimbabwe: challenges and opportunities from the field.

B Nyagadza, N Kudya, E Mbofana, S Masaka, D Garone, C-Y Chen, A Mulingwa, C Uzande, P Isaakidis, Z Ndlovu

Registry-linked trialAbstract read
In one paragraph

Article in Public health action, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05278559 (Can Undetectable), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05278559 unknown statusnot on this mapstarted 2022, after this paper: background citation

Can Undetectable (Viral Load) = Untransmissible (Virus) Change the Life Course of Adolescents Living the HIV in Africa

TypeobservationalSponsorCentre for Sexual Health and HIV/AIDS Research ZimbabweRan2022 to 2024Enrolled300ConditionsHIV/AIDS
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

B NyagadzaMédecins Sans Frontières (MSF), Mutare, Zimbabwe.
N KudyaMédecins Sans Frontières (MSF), Mutare, Zimbabwe.
E MbofanaMédecins Sans Frontières (MSF), Mutare, Zimbabwe.
S MasakaMédecins Sans Frontières (MSF), Mutare, Zimbabwe.
D GaroneMSF, Harare, Zimbabwe.
C-Y ChenMSF, Harare, Zimbabwe.
A MulingwaMinistry of Health and Child Care, Zimbabwe.
C UzandeMinistry of Health and Child Care, Zimbabwe.
P IsaakidisMSF, Southern Africa Medical Unit, Cape Town, South Africa.
Z NdlovuMSF, Southern Africa Medical Unit, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDemand for viral load (VL) monitoring is expected to increase; however, implementation of the multifaceted VL testing poses numerous challenges. We report experiences from Médecins Sans Frontiéres (MSF) and partners in the scale-up of HIV VL in collaboration with the Ministry of Health and Child Care (MoHCC) of Zimbabwe.

methodsA retrospective data review of routine reports from MSF-supported health facilities in Manicaland Province (Zimbabwe) was conducted. These secondary aggregate data were triangulated, and emerging themes of lessons learnt from VL monitoring were shared.

resultsA VL testing coverage of 63% (5966/9456) was achieved among the 40 health facilities, together with a switch rate to second-line antiretroviral therapy (ART) of 46.4% (108/233). The key enablers to scaling-up the VL monitoring were well-equipped and supported VL laboratories, the operationalisation of the on-the-job clinical mentoring and systematic weaning off of better performing health facilities. Concerted efforts from different implementing partners and funders in the HIV programme, and close collaboration with MoHCC were pivotal.

conclusionOur experience indicates that clinical mentoring is effective, and resulted in high VL testing coverage and up-skilling primary health care workers in VL monitoring. Attention must be focused on innovations for improving VL result utilisation, especially the identification and management of patients who fail ART.

Indexed as

clinical mentoringdried blood spotHIV treatment cascadeHIV viral loadlow-resource settingspartner collaborationVL monitoring scale-up

Identifiers

PMID32042612
PMCPMC6945735

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.