ArticleAnnals of medicine and surgery (2012)2020
Antinociceptive effects of green synthesized copper nanoparticles alone or in combination with morphine.
Article in Annals of medicine and surgery (2012), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 31 citations in OpenAlex.
- A Review on Bioflocculant-Synthesized Copper Nanoparticles: Characterization and Application in Wastewater Treatment.Bioengineering (Basel, Switzerland) · 2024Review
- Antinociceptive and anti-inflammatory activities of the methanol extract ofArchives of Razi Institute · 2024Article
- Antibiofilm activity of biosynthesized silver and copper nanoparticles using Streptomyces S29.AMB Express · 2023Article
- Therapeutic Potential of Green Synthesized Copper Nanoparticles Alone or Combined with Meglumine Antimoniate (GlucantimeNanomaterials (Basel, Switzerland) · 2021Article
- Effect of gold nanoparticles (AuNPs) on isolated rat tracheal segments.Toxicology reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate the antinociceptive effect of biosynthetic copper nanoparticles from aqueous extract of
methodsIn this study, green synthesis of copper nanoparticles (CuNPs) was performed using
resultsThe obtained maximum peak at the wavelength of 414 nm demonstrated the biosynthesis of the copper nanoparticles. SEM approved the particle size of CuNPs between 17 and 41 nm. The statistical analyses of the data of hot plate and tail-flick tests showed the potent analgesic effect of biosynthetic CuNPs. In this regard, the antinociceptive effect of at the doses of 75 mg/kg and 25 mg/kg plus morphine was significantly higher in comparison with the control group receiving morphine alone (P < 0.05). No significant (p > 0.05) difference was observed after the administration of CuNPs at the doses of 25, 50, and 75 mg/kg in the sensory-motor test.
conclusionThe present investigation demonstrated the analgesic effects of CuNPs especially in combination with morphine. These findings can provide a new strategy for producing new antinociceptive medications in the future.
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Registered trials
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