Evidence map›Paper›PMID 32042324›Full record

ArticleTheranostics2020

Aligned chitosan nanofiber hydrogel grafted with peptides mimicking bioactive brain-derived neurotrophic factor and vascular endothelial growth factor repair long-distance sciatic nerve defects in rats.

Feng Rao, Yanhua Wang, Dianying Zhang, Changfeng Lu, Zheng Cao, Jiajie Sui, Mengjiao Wu, Yawen Zhang, Wei Pi, Bo Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 199 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Peptide-Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. [Research progress in auxiliary components of nerve conduit for treating peripheral nerve injuries].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Feng RaoDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Yanhua WangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Dianying ZhangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Changfeng LuDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Zheng CaoState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Jiajie SuiState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Mengjiao WuKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Yawen ZhangDepartment of Orthopedics, Peking University Third Hospital, Beijing100191, China.
Wei PiDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Bo WangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Yuhui KouDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Xiumei WangState Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Peixun ZhangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Baoguo JiangDepartment of Orthopedics and Trauma, Peking University People's Hospital, Beijing100044, China.
Peking University · CNPeking University People's Hospital · CNState Key Laboratory of New Ceramics and Fine ProcessingPeking University Cancer Hospital · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous nerve transplantation, which is the gold standard for clinical treatment of peripheral nerve injury, still has many limitations. In this study, aligned chitosan fiber hydrogel (ACG) grafted with a bioactive peptide mixture consisting of RGI (Ac-RGIDKRHWNSQGG) and KLT (Ac-KLTWQELYQLKYKGIGG), designated as ACG-RGI/KLT, was used as nerve conduit filler to repair sciatic nerve defects in rats.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorChitosanHydrogelsNanofibersNerve RegenerationNerve TissuePeptidesPeripheral Nerve InjuriesRatsRecovery of FunctionSchwann CellsSciatic NerveStress, MechanicalVascular Endothelial Growth Factor ABDNF protein, humanBrain-Derived Neurotrophic FactorChitosanHydrogelsPeptidesVascular Endothelial Growth Factor Achitosan nanofiberselectrospinningmechanical stretchingpeptides.Peripheral nerve injury

Identifiers

PMID32042324
PMCPMC6993237
OpenAlexW2997773365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.