ArticleIranian journal of veterinary research2019
Substance P as a potential biomarker of pain assessment in dogs.
Article in Iranian journal of veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Analysis of serum biomarkers associated with pain in Spanish greyhounds undergoing ovariohysterectomy.The Veterinary record · 2026Article
- Neuro-immune-bone axis in post-traumatic bone regeneration: temporal regulation, dysregulation mechanisms, and therapeutic implications.Frontiers in immunology · 2026Review
- Comparison of outcomes between laparotomic and laparoscopic elective ovariectomy in anestrus dogs: postoperative recovery, pain and inflammatory biomarkers.Veterinary research communications · 2025Article
- The Role of Biomarkers in Acute Pain: A Narrative Review.Pain and therapy · 2025Review
- Effect of classical music on light-plane anaesthesia and analgesia in dogs subjected to surgical nociceptive stimuli.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubstance P (SP) is a neuropeptide that functions as a neuromodulator. It is released mainly in the brain stem and in nerve endings.
aimsThe present study aimed to provide fundamental data that may be applied to the assessment of pain in dogs by evaluating their serum SP concentrations.
methodsTwo groups of dogs were designated as pain groups that included 10 dogs with medial patella luxation (MPL) and 10 dogs with fractures, respectively, and 20 healthy dogs were enrolled as the control group.
resultsThe SP concentrations in the serum of the pain groups reached 485.5 ± 250.1 pg/ml that was significantly higher than those of the control group, which reached 116.4 ± 38.5 pg/ml. In particular, serum SP concentrations in dogs with fractures (663.3 ± 225.3 pg/ml) were significantly higher compared to those of dogs with MPL (307.8 ± 105.3 pg/ml), indicating that serum SP levels increased when the dogs experienced greater pain.
conclusionThese findings propose the possibility that SP might be a useful biomarker for pain assessment in dogs. The present study may provide fundamental data that can aid in future pain management in dogs.
Indexed as
Identifiers
32042294PMC6983313W3012445059What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.