ArticleNature structural & molecular biology2020
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.
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Article in Nature structural & molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98citing papers in PubMed
17.4field-weighted citation impact, top 1% of its field
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Who cites it
98 citing papers in PubMed, 138 citations in OpenAlex.
- Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons.iScience · 2026Article
- AcutebioRxiv : the preprint server for biology · 2026Article
- Transposable Element Activation: A Hallmark of Cancer.Cancer discovery · 2026Review
- LINE-1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements.Nature communications · 2026Article
- The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026Review
- LINE-1 retrotransposons: Multifaceted functions and regulatory mechanisms in health and disease.Molecular therapy. Nucleic acids · 2026Review
- A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways.GeroScience · 2026Article
- The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism.Nucleic acids research · 2026Article
- MORC2 promotes acute myeloid leukemia by silencing LINE-1 retrotransposon.Functional & integrative genomics · 2026Article
- Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons.Nucleic acids research · 2026Article
- Transposable elements as a possible missing link between genetic predisposition and environmental triggers of autoimmune disorders: insights from type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis.Frontiers in immunology · 2026Review
- Jumping in the human brain: A review on somatic transposition.Fundamental research · 2026Review
- Transposable Element Dysregulation in Hepatocellular Carcinoma: Epigenetic Mechanisms, Immune Remodeling, and Translational Opportunities.Journal of hepatocellular carcinoma · 2026Review
- Article
- Unraveling LINE-1 retrotransposition in head and neck squamous cell carcinoma.Molecular oncology · 2025Article
- Revisiting Clonal Evolution Through the Light of Retrotransposons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Dynamic remodelling of epithelial plasticity in colorectal cancer from single-cell and spatially resolved perspectives.Journal of translational medicine · 2025Article
- Enhancer activation from transposable elements in extrachromosomal DNA.Nature cell biology · 2025Article
- A multi-omics analysis of human fibroblasts overexpressing anbioRxiv : the preprint server for biology · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Daniel ArdeljanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ardeljan@jhmi.edu.ORCID http://orcid.org/0000-0002-5593-421X
Jared P SterankaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chunhong LiuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhi LiInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York City, NY, USA.
Martin S TaylorDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1560-9276
Lindsay M PayerDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mikhail GorbounovDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacob S SarneckiDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Vikram DeshpandeDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Ralph H HrubanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4554-5672
Jef D BoekeInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York City, NY, USA.ORCID http://orcid.org/0000-0001-5322-4946
David FenyöInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York City, NY, USA.ORCID http://orcid.org/0000-0001-5049-3825
Pei-Hsun WuJohns Hopkins Physical Sciences Oncology Center, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7371-2960
Agata SmogorzewskaLaboratory of Genome Maintenance, The Rockefeller University, New York City, NY, USA.
Andrew J HollandDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3728-6367
Kathleen H BurnsDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. kburns@jhmi.edu.ORCID http://orcid.org/0000-0003-1620-3761
Johns Hopkins University · USInstitute for Systems Biology · USMassachusetts General Hospital · USRockefeller University · US
Funding
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4MTRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1MTraining CoreP50GM107632 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BOEKE, JEF D · 2013 to 2017
$10.0MThe Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI GERECHT, SHARON · 2016 to 2020
$9.9MT32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5MCentrosome biogenesis and copy number controlR01GM114119 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORMACK, BRENDAN · 2015 to 2023
$3.3MOpportunities for Pathology Trainees in Cancer ResearchT32CA193145 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A., EBERHART, CHARLES G · 2015 to 2025
$2.6MMolecular mechanism that suppresses the proliferation of cells with supernumerary centriolesR01GM133897 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORMACK, BRENDAN · 2019 to 2022
$1.9MExpression and Impact of Interspersed RepeatsR01GM130680 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BURNS, KATHLEEN H · 2019 to 2022
$1.4MT-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2MLINE-1 genotoxicity and cytotoxicity and its relevance to cancerF30CA221175 · NCI · JOHNS HOPKINS UNIVERSITY · PI ARDELJAN, DANIEL · 2017 to 2020
$150kNCI NIH HHS F30 CA221175NCI NIH HHS T32 CA009110NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952NCI NIH HHS T32 CA193145NCI NIH HHS U54 CA210173NIA NIH HHS P01 AG051449NIGMS NIH HHS P50 GM107632NIGMS NIH HHS R01 GM114119NIGMS NIH HHS R01 GM130680NIGMS NIH HHS R01 GM133897
Abstract
LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that nontransformed cells undergo a TP53-dependent growth arrest and activate interferon signaling in response to LINE-1. TP53 inhibition allows LINE-1
Indexed as
Long Interspersed Nucleotide ElementsCell Line, TumorCell ProliferationDNADNA ReplicationG1 Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticHEK293 CellsHeLa CellsHumansNeoplasmsSignal TransductionTumor Suppressor Protein p53DNATP53 protein, humanTumor Suppressor Protein p53
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.