Evidence map›Paper›PMID 32042135›Full record

ArticleNature chemistry2020

Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists.

Benjamin J Huffman, Shuming Chen, J Luca Schwarz, R Erik Plata, Emily N Chin, Luke L Lairson, K N Houk, Ryan A Shenvi

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  3. Taking the STING out of neurodegenerative disease.The Journal of experimental medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Benjamin J HuffmanDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Shuming ChenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
J Luca SchwarzDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
R Erik PlataDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Emily N ChinDepartment of Chemistry, Scripps Research, La Jolla, CA, USA.
Luke L LairsonDepartment of Chemistry, Scripps Research, La Jolla, CA, USA. llairson@scripps.edu.ORCID http://orcid.org/0000-0001-6701-996X
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA. houk@chem.ucla.edu.ORCID http://orcid.org/0000-0002-8387-5261
Ryan A ShenviDepartment of Chemistry, Scripps Research, La Jolla, CA, USA. rshenvi@scripps.edu.ORCID http://orcid.org/0000-0001-8353-6449
Scripps Institution of Oceanography · USScripps Research Institute · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

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Identifiers

PMID32042135
OpenAlexW3005220548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.