ArticleThe ISME journal2020
Role of glucosyltransferase R in biofilm interactions between Streptococcus oralis and Candida albicans.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Peri-implantitis progression and modulating factors: evidence synthesis and implications for clinical management.Brazilian oral research · 2026Review
- Microbiome modulation of implant-related infection by a novel miniaturized pulsed electromagnetic field device.NPJ biofilms and microbiomes · 2025Article
- The Effect of Xanthohumol and Thymol onCells · 2024Article
- Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections.Pharmaceutics · 2024Review
- Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium.Scientific reports · 2024Article
- The Impact ofInternational journal of molecular sciences · 2024Article
- Surface adherence and vacuolar internalization of bacterial pathogens to the Candida spp. cells: Mechanism of persistence and propagation.Journal of advanced research · 2023Review
- The interactions of Candida albicans with gut bacteria: a new strategy to prevent and treat invasive intestinal candidiasis.Gut pathogens · 2023Review
- Article
- Potential Application of the WST-8-mPMS Assay for Rapid Viable Microorganism Detection.Pathogens (Basel, Switzerland) · 2023Article
- Exopolysaccharides metabolism and cariogenesis ofJournal of oral microbiology · 2023Article
- Roles ofFrontiers in cellular and infection microbiology · 2023Review
- Epidemic Trends and Biofilm Formation Mechanisms of Haemophilus influenzae: Insights into Clinical Implications and Prevention Strategies.Infection and drug resistance · 2023Review
- Effect of surface stiffness in initial adhesion of oral microorganisms under various environmental conditions.Colloids and surfaces. B, Biointerfaces · 2023Article
- Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain?iScience · 2022Review
- Interactions betweenFrontiers in microbiology · 2022Review
- Recent Advances and Opportunities in the Study ofFrontiers in cellular and infection microbiology · 2022Review
- Insights From theFrontiers in microbiology · 2022Review
- Understanding Lactobacillus paracasei and Streptococcus oralis Biofilm Interactions through Agent-Based Modeling.mSphere · 2021Article
- Transcriptomic Responses to Coaggregation between Streptococcus gordonii and Streptococcus oralis.Applied and environmental microbiology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Streptococcal glucosyltransferases (Gtf) synthesize α-glucan exopolymers which contribute to biofilm matrix. Streptococcus oralis interacts with the opportunistic pathogen Candida albicans to form hypervirulent biofilms. S. oralis 34 has a single gtf gene (gtfR). However, the role of gtfR in single and mixed species biofilms with C. albicans has never been examined. A gtfR deletion mutant, purified GtfR, and recombinant GtfR glucan-binding domain were tested in single and mixed biofilms on different substrata in vitro. A mouse oral infection model was also used. We found that in single species biofilms growing with sucrose on abiotic surfaces S. oralis gtfR increased biofilm matrix, but not bacterial biomass. In biofilms with C. albicans, S. oralis encoding gtfR showed increased bacterial biomass on all surfaces. C. albicans had a positive effect on α-glucan synthesis, and α-glucans increased C. albicans accretion on abiotic surfaces. In single and mixed infection of mice receiving sucrose S. oralis gtfR enhanced mucosal burdens. However, sucrose had a negative impact on C. albicans burdens and reduced S. oralis burdens in co-infected mice. Our data provide new insights on the GtfR-mediated interactions between the two organisms and the influence of biofilm substratum and the mucosal environment on these interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.