Evidence map›Paper›PMID 32042083›Full record

ArticleEuropean journal of human genetics : EJHG2020

The genetic history of France.

Aude Saint Pierre, Joanna Giemza, Isabel Alves, Matilde Karakachoff, Marinna Gaudin, Philippe Amouyel, Jean-François Dartigues, Christophe Tzourio, Martial Monteil, Pilar Galan and 5 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Article
  11. Towards a fine-scale picture of European genetic diversity.European journal of human genetics : EJHG · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Aude Saint PierreUniv Brest, Inserm, EFS, CHU Brest, UMR 1078, GGB, F-29200, Brest, France. aude.saintpierre@univ-brest.fr.ORCID http://orcid.org/0000-0002-8569-2936
Joanna Giemza *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Isabel Alves *Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Matilde KarakachoffUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Marinna GaudinUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Philippe AmouyelUniv. Lille, Inserm, CHU Lille University Hospital, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167 - RID-AGE-Risk factors and molecular determinants of aging-related, F-59000, Lille, France.
Jean-François DartiguesUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.
Christophe TzourioUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.
Martial MonteilUniversité de Nantes, UMR 6566 CReAAH, LARA, Nantes, France.
Pilar GalanUniversité Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, F-93017, Bobigny, France.
Serge HercbergUniversité Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, F-93017, Bobigny, France.
Iain MathiesonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Richard RedonUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.
Emmanuelle Génin *Univ Brest, Inserm, EFS, CHU Brest, UMR 1078, GGB, F-29200, Brest, France.ORCID http://orcid.org/0000-0003-4117-2813
Christian DinaUniversité de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France. christian.dina@univ-nantes.fr.ORCID http://orcid.org/0000-0002-7722-7348
Centre National de la Recherche Scientifique · FRInserm · FRUniversité de Bordeaux · FRCentre de Recherche en Archéologie, Archéosciences, Histoire · FRUniversity of Pennsylvania · US

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-16-CE12-0033
6 · The paper itself

Abstract

The study of the genetic structure of different countries within Europe has provided significant insights into their demographic history and population structure. Although France occupies a particular location at the western part of Europe and at the crossroads of migration routes, few population genetic studies have been conducted so far with genome-wide data. In this study, we analyzed SNP-chip genetic data from 2184 individuals born in France who were enrolled in two independent population cohorts. Using FineSTRUCTURE, six different genetic clusters of individuals were found that were very consistent between the two cohorts. These clusters correspond closely to geographic, historical, and linguistic divisions of France, and contain different proportions of ancestry from Stone and Bronze Age populations. By modeling the relationship between genetics and geography using EEMS, we were able to detect gene flow barriers that are similar across the two cohorts and correspond to major rivers and mountain ranges. Estimations of effective population sizes also revealed very similar patterns in both cohorts with a rapid increase of effective population sizes over the last 150 generations similar to other European countries. A marked bottleneck is also consistently seen in the two datasets starting in the 14

Indexed as

GenotypePopulation DynamicsEvolution, MolecularFranceHumansPedigreePolymorphism, GeneticPopulation

Identifiers

PMID32042083
PMCPMC7316781
OpenAlexW3004717443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.