ArticleScientific reports2020
Modification of the head proteome of nurse honeybees (Apis mellifera) exposed to field-relevant doses of pesticides.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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14 citing papers in PubMed, 65 citations in OpenAlex.
- Impact of the pesticide fipronil on honey quality and the survival of Apis mellifera bees.Environmental science and pollution research international · 2026Article
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- Integrative Omics and AI-Driven Systems Biology: Multilayer Networks DecodingJournal of proteome research · 2025Review
- Autophagy is involved in the toxicity of the biocontrol agent GC16 against Tetranychus pueraricola (Acari: Tetranychidae) based on transcriptomic and proteomic analyses.BMC genomics · 2025Article
- Comparative Proteomics of Resistant and Susceptible Strains of Frankliniella occidentalis to Abamectin.Electrophoresis · 2025Article
- Honey bee colony behavior and ontogeny are adversely affected when exposed to a pesticide-contaminated environment.Journal of insect science (Online) · 2024Article
- Metalloproteomic analysis of liver proteins isolated from broilers fed with different sources and levels of copper and manganese.Scientific reports · 2024Article
- Parasite and Pesticide Impacts on the Bumblebee (International journal of molecular sciences · 2023Article
- Unraveling theInternational journal of molecular sciences · 2023Article
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- Activities of Antioxidant and Proteolytic Systems and Biomarkers in the Fat Body and Hemolymph of YoungAnimals : an open access journal from MDPI · 2022Article
- Transcriptome responses to heat and cold stress in prepupae ofEcology and evolution · 2021Article
- Antioxidation Defenses ofAnimals : an open access journal from MDPI · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the effect of pesticides on the survival of honeybee colonies is important because these pollinators are reportedly declining globally. In the present study, we examined the changes in the head proteome of nurse honeybees exposed to individual and combined pesticides (the fungicide pyraclostrobin and the insecticide fipronil) at field-relevant doses (850 and 2.5 ppb, respectively). The head proteomes of bees exposed to pesticides were compared with those of bees that were not exposed, and proteins with differences in expression were identified by mass spectrometry. The exposure of nurse bees to pesticides reduced the expression of four of the major royal jelly proteins (MRJP1, MRJP2, MRJP4, and MRJP5) and also several proteins associated with carbohydrate metabolism and energy synthesis, the antioxidant system, detoxification, biosynthesis, amino acid metabolism, transcription and translation, protein folding and binding, olfaction, and learning and memory. Overall, when pyraclostrobin and fipronil were combined, the changes in protein expression were exacerbated. Our results demonstrate that vital proteins and metabolic processes are impaired in nurse honeybees exposed to pesticides in doses close to those experienced by these insects in the field, increasing their susceptibility to stressors and affecting the nutrition and maintenance of both managed and natural colonies.
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