ArticleScientific reports2020
The effect of group size, age and handling frequency on inter-male aggression in CD 1 mice.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Laboratory conditions matter: social housing in male and female laboratory mice in a multicenter study approach.Lab animal · 2026Article
- Influence of environmental enrichment on rodents' brains: neurochemical and neuroanatomical aspects.Frontiers in veterinary science · 2026Review
- Addressing cultural and knowledge barriers to enable preclinical sex inclusive research.eLife · 2025Article
- Social Housing of Male CD-1 Mice (Mus musculus) in the Toxicological Setting: A 28-Day Social Compatibility Study of Male Mice following Oral Gavage of Theophylline.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A customised combination of environmental enrichment reduces aggression in CD-1 male mice.Laboratory animals · 2025Article
- Inhibition of efflux pumps by FDA-approved drugs oxiconazole and sertaconazole restores antibiotic susceptibility in multidrug-resistantAntimicrobial agents and chemotherapy · 2025Article
- Article
- Genotype-Based Housing as a Potential Confounder in Studies Using Transgenic Mouse Models-Insight from the A53T Mouse Model of Parkinson's Disease.Biomedicines · 2025Article
- Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus.EBioMedicine · 2025Article
- Improved Memory and Lower Stress Levels in Male Mice Co-Housed with Ovariectomized Female Mice.Animals : an open access journal from MDPI · 2024Article
- SGLT1/2 inhibition improves glycemic control and multi-organ protection in type 1 diabetes.iScience · 2023Article
- miRNA-132/212 Deficiency Disrupts Selective Corticosterone Modulation of Dorsal vs. Ventral Hippocampal Metaplasticity.International journal of molecular sciences · 2023Article
- Effects of Group Size on Behavior, Reproduction, and mRNA Expression in Brains of Brandt's Voles.Brain sciences · 2023Article
- Identification of Rodent Husbandry Refinement Opportunities through Benchmarking and Collaboration.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Location bias contributes to functionally selective responses of biased CXCR3 agonists.Nature communications · 2022Article
- Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice.Molecules (Basel, Switzerland) · 2022Article
- Exploring Refinement Strategies for Single Housing of Male C57BL/6JRj Mice: Effect of Cage Divider on Stress-Related Behavior and Hypothalamic-Pituitary-Adrenal-Axis Activity.Frontiers in behavioral neuroscience · 2021Article
- Who's the Boss? Assessing Convergent Validity of Aggression Based Dominance Measures in Male Laboratory Mice,Frontiers in veterinary science · 2021Article
- Review
- Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggression in male mice often leads to injury and death, making social housing difficult. We tested whether (1) small group size, (2) early age of allocation to a group decreases aggression and 3) manipulation increases aggression in male mice. A 14wk study was performed to assess the following conditions in male CD-1/ICR mice: group size (1, 2, or 3), age at grouping (5 or 7wks), and manipulation (daily scruffing or minimal weekly handling). Wounds, body weights, food consumption, nest scores, sucrose consumption, fecal corticosterone and blood for hematology were collected. At the end of the study, mice were euthanized and pelted to assess wounding with the pelt aggression lesion scale (PALS). No signs of acute or chronic stress were observed in any of the groups. Trio housed mice showed less bite wounds than pair housed mice. In general, mice in larger groups ate less but weighed more. Individually housed mice, however, had high nest scores, low body weights, and increased sucrose and food consumption. These results suggest that even when nesting material is provided, individual mice may be experiencing thermal stress. Based on this data, CD-1 mice can successfully be housed for up to 14wks and groups of 3 may be the best for reducing even minor levels of aggression (i.e. wounding).
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