ArticleScientific reports2020
Integrated LC-MS and GC-MS-based untargeted metabolomics studies of the effect of azadirachtin on Bactrocera dorsalis larvae.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
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- Research on the mechanism of Guanyu Zhixie Granule in intervening gastric ulcers in rats based on network pharmacology and multi-omics.Frontiers in veterinary science · 2024Article
- GC-MS based untargeted metabolomics reveals the metabolic response of earthworm (Eudrilus eugeniae) after chronic combinatorial exposure to three different pesticides.Scientific reports · 2023Article
- Metabolomics Provides New Insights into Host Manipulation Strategies byMetabolites · 2023Article
- In the Swim of Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations of Zebrafish Larvae Exposed to THC for the Assessment of Its Potential Environmental and Human Health Impact.Molecules (Basel, Switzerland) · 2022Article
- Metabolomics Research in Periodontal Disease by Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Review
- Metabolomics approach to assess the effect of siphonal autotomy on metabolic characteristics of razor clam Solen grandis.Scientific reports · 2022Article
- Metabolomics Reveals Changes in Metabolite Profiles among Pre-Diapause, Diapause and Post-Diapause Larvae ofInsects · 2022Article
- Status and Prospects of Botanical Biopesticides in Europe and Mediterranean Countries.Biomolecules · 2022Review
- Metabolic Changes in Larvae of PredatorMetabolites · 2022Article
- A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy.Frontiers in endocrinology · 2022Review
- Transcriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis inFrontiers in plant science · 2022Article
- GC/TOF-MS-Based Metabolomics Reveals Altered Metabolic Profiles in Wood-Feeding TermiteInsects · 2021Article
- Review
- The Biosynthesis and Metabolism of theFrontiers in molecular biosciences · 2021Review
- Beyond Sperm and Male Accessory Gland Proteins: Exploring Insect Reproductive Metabolomes.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Azadirachtin exhibits excellent bioactivities against several hundred arthropods. However, current knowlege of its biochemical effect on B. dorsalis larvae is not deep enough. In this study, integrated LC-MS and GC-MS-based untargeted metabolomics were used to analyze the changes of endogenous metabolites and the biochemical effects of azadirachtin on B. dorsalis larvae. Azadirachtin has excellent bioactivities against B. dorsalis larvae in this study, leading to a longer developmental duration, lower survival rate, and low pupa weight. The effect of azadirachtin was investigated on a total of 22 and 13 differentially abundant metabolites in the LC-MS and GC-MS-based metabolomics results, are selected respectively. Pathway analysis indicated that 14 differentially enriched metabolic pathways, including seven influential pathways, are worthy of attention. Further integrated key metabolic pathway analysis showed that histidine metabolism, D-glutamine and D-glutamate metabolism, biotin metabolism, ascorbate and aldarate metabolism, pentose and glucuronate interconversions, and alanine, aspartate and glutamate metabolism in B. dorsalis larvae are significantly relevant pathways affected by azadirachtin. Although extrapolating the bioactivity results in this study to the practical project of B. dorsalis pest management in the field has limitations, it was found that azadirachtin has a significant effect on the primary metabolism of B. dorsalis larvae.
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